{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:05:23Z","timestamp":1784307923659,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Dialysis\u2010related amyloidosis (DRA) results from \u03b22\u2010microglobulin accumulation in patients on long\u2010term hemodialysis, typically manifesting after 5\u201310\u2009years. While well\u2010documented in developed countries, reports from sub\u2010Saharan Africa remain scarce. We report a 45\u2009year\u2010old Burkinabe man with 8\u2009years of maintenance hemodialysis who presented with severe diffuse bone pain and inflammatory polyarthralgia affecting shoulders, hips, knees, and wrists. Physical examination revealed diffuse spinal tenderness and restricted painful joint mobility with bilateral positive Patrick's and key signs. Laboratory investigations showed elevated C\u2010reactive protein and markedly elevated serum \u03b22\u2010microglobulin, with negative rheumatoid factor, anti\u2010CCP antibodies, and antinuclear antibodies. MRI demonstrated characteristic band\u2010like vertebral infiltration with preserved disc spaces and extensive nodular involvement of the sacrum, iliac wings, and proximal femurs. Despite unavailable bone biopsy, probable DRA diagnosis was established based on prolonged low\u2010flux hemodialysis, markedly elevated \u03b22\u2010microglobulin, characteristic imaging, and exclusion of alternative diagnoses including AL and AA amyloidosis. Treatment with celecoxib 200\u2009mg daily achieved significant improvement at 1\u2009month follow\u2010up. This case highlights probable DRA as an important cause of diffuse bone pain in younger African dialysis patients. Clinicians should maintain high suspicion for DRA in patients with polyarticular symptoms after long\u2010term dialysis, utilizing \u03b22\u2010microglobulin measurement and MRI for diagnosis when histological confirmation is unavailable.<\/jats:p>","DOI":"10.1002\/ccr3.72994","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T02:40:11Z","timestamp":1781923211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Unusual Cause of Diffuse Bone Pain in a Long\u2010Term Dialysis Patient: A Case Report of \u03b22\u2010Microglobulin Amyloid Arthropathy"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9095-8948","authenticated-orcid":false,"given":"Yannick Laurent Tchenadoyo","family":"Bayala","sequence":"first","affiliation":[{"name":"Rheumatology Department Bogodogo University Hospital Center  Ouagadougou Burkina 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