{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:25:56Z","timestamp":1787120756161,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Lynch syndrome (LS), a well\u2010known cancer risk syndrome, is caused by deleterious germline mutations in the mismatch repair genes. LS predispose patients to various types of cancers including colon adenocarcinoma. We discuss the case of a woman with LS who also developed a non\u2010functioning pancreatic neuroendocrine tumor (P\u2010NET) following primary colon adenocarcinoma. Multiple liver lesions were discovered 6\u2009months following surgical excision the pancreatic mass and were later determined to be a neuroendocrine tumor. Liver lesions shrank after treatment with octreotide and Lutetium\u2010177 vipivotide tetraxetan. She is in remission and takes positron emission tomography scans every 6\u2009months for monitoring. This case highlights the importance of LS genetic testing, the function of microsatellite instability (MSI) as a screening marker, and the need for additional study on the relationship between LS and P\u2010NETs, particularly through advanced molecular testing to confirm lesion relationships. The role of microsatellite instability (MSI) as a screening marker, and personalized treatment approaches like immunotherapy for dMMR tumors. Understanding these correlations may assist in early discovery, surveillance, and customized treatment for patients dealing with LS\u2010associated malignancies.<\/jats:p>","DOI":"10.1002\/ccr3.73036","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T04:13:19Z","timestamp":1782792799000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metastatic Unfunctional Pancreatic Neuroendocrine Tumor in Lynch Syndrome"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4297-7154","authenticated-orcid":false,"given":"Fateme","family":"Salemi","sequence":"first","affiliation":[{"name":"Hematology, Oncology and Stem Cell Transplantation Research Center, Research Institute for Oncology, Hematology and Cell Therapy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3014-7954","authenticated-orcid":false,"given":"Zahra","family":"Sadin","sequence":"additional","affiliation":[{"name":"Hematology, Oncology and Stem Cell Transplantation Research Center, Research Institute for Oncology, Hematology and Cell Therapy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atefe","family":"Barzegari","sequence":"additional","affiliation":[{"name":"Department of Stem Cells and Developmental Biology Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mohammad Reza","family":"Mortazavizadeh","sequence":"additional","affiliation":[{"name":"Department of Stem Cells and Developmental Biology Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massih","family":"Bahar","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Islamic Azad University, Yazd Branch  Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motahare","family":"Amiri","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Tehran University of Medical Sciences, Faculty of Medicine  Tehran Iran"},{"name":"Department of Operative Dentistry, School of Dentistry Shahid Sadoughi University of Medical Sciences  Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.0b013e31823375ea"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604860"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1897-4287-7-12"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2009.01230.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes14051025"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2009.03392.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.757804"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgm228"},{"issue":"5","key":"e_1_2_11_10_1","article-title":"Pancreatic Non\u2010Functioning Neuroendocrine Tumor: A New Entity Genetically Related to Lynch Syndrome","volume":"8","author":"Serracant Barrera A.","year":"2017","journal-title":"Journal of Gastrointestinal Oncology"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443171"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2011.12.012"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh034"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.1063"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.20750"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22105246"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13102418"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15215232"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2016-0046"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.21037\/jgo.2017.07.02"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44276-025-00171-0"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13092242"},{"key":"e_1_2_11_23_1","article-title":"Underdiagnosis of Hereditary Colorectal Cancers Among Medicare Patients: Genetic Testing Criteria for Lynch Syndrome Miss the Mark","volume":"5","author":"Muller C.","year":"2021","journal-title":"JCO Precision Oncology"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73036","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.73036","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T05:36:06Z","timestamp":1787117766000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.73036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/ccr3.73036"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.73036","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,29]]},"assertion":[{"value":"2025-11-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e73036"}}