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Phenobarbital is one of the most common anti\u2010epileptic drugs that has numerous adverse drug reactions, including toxic epidermal necrolysis. The event is rare and a medical emergency. A six\u2010year\u2010old female epileptic child with phenobarbital\u2010induced toxic epidermal necrolysis was referred for the management of diffuse exfoliative lesions involving her eyes and buccal mucosa. Associated with the skin lesions, the patient reported high\u2010grade fever, reddish eye discoloration, dysphagia and dry cough. The exfoliative skin lesion involved 90% of her total body surface area. The patient was managed with withdrawal of phenobarbital, IV antibiotics, systemic corticosteroid, twice daily wound care, analgesic, and nutritional support. Early recognition, discontinuation of offending medications and prompt intervention are crucial to mitigate harm. Raising awareness about ADRs and their management is vital for enhancing patient safety and outcomes.<\/jats:p>","DOI":"10.1002\/ccr3.73048","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:35:59Z","timestamp":1782477359000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Phenobarbital\u2010Induced Toxic Epidermal Necrolysis: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5586-2964","authenticated-orcid":false,"given":"Biniyam Tedla","family":"Mamo","sequence":"first","affiliation":[{"name":"Ethiopian Food and Drug Administration  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8198-2848","authenticated-orcid":false,"given":"Solomon Getnet","family":"Meshesha","sequence":"additional","affiliation":[{"name":"Ethiopian Food and Drug Administration  Addis 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