{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:25:53Z","timestamp":1787120753058,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Crohn's disease (CD) is a chronic autoimmune inflammatory bowel disease (IBD) with significant diagnostic and therapeutic challenges. We reported a case of a 20\u2010year\u2010old Bangladeshi male with an 8\u2010month history of severe upper abdominal pain, bowel discomfort, and intermittent low\u2010grade fever. Initial investigations showed mild anemia and elevated inflammatory markers. Magnetic resonance enterography revealed distal small bowel thickening, suggestive of IBD. Colonoscopy and biopsy confirmed chronic ileitis without granulomas and an ulcer at the terminal ileum. Despite the absence of granulomas, clinical symptoms, elevated fecal calprotectin, and high C\u2010reactive protein (CRP)\u00a0led to a diagnosis of CD. The disease later progressed to a perianal abscess, a fistulizing complication. The patient received three doses of infliximab but subsequently discontinued therapy. He remained untreated for 3\u2010years and subsequently developed an intestinal perforation requiring right hemicolectomy with ileostomy. Following ileostomy reversal, adalimumab was advised. This case highlighted the diagnostic and therapeutic challenges of CD in Bangladesh.<\/jats:p>","DOI":"10.1002\/ccr3.73049","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:57:49Z","timestamp":1782791869000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Challenges in Diagnosis and Management of Crohn's Disease in Bangladesh With Long Term Follow\u2010Up"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9837-4584","authenticated-orcid":false,"given":"Imtiaz","family":"Abdullah","sequence":"first","affiliation":[{"name":"Gut\u2010Brain Axis Laboratory, Infectious Diseases Division, icddr,b  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1282-3157","authenticated-orcid":false,"given":"Imran","family":"Hasan","sequence":"additional","affiliation":[{"name":"Gut\u2010Brain Axis Laboratory, Infectious Diseases Division, icddr,b  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2832-7254","authenticated-orcid":false,"given":"Mantaka","family":"Rahman","sequence":"additional","affiliation":[{"name":"Gut\u2010Brain Axis Laboratory, Infectious Diseases Division, icddr,b  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1064-9009","authenticated-orcid":false,"given":"Shoma","family":"Hayat","sequence":"additional","affiliation":[{"name":"Gut\u2010Brain Axis Laboratory, Infectious Diseases Division, icddr,b  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6619-0589","authenticated-orcid":false,"given":"Nowshin","family":"Papri","sequence":"additional","affiliation":[{"name":"Gut\u2010Brain Axis Laboratory, Infectious Diseases Division, icddr,b  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nusrat","family":"Fatema","sequence":"additional","affiliation":[{"name":"Gut\u2010Brain Axis Laboratory, Infectious Diseases Division, icddr,b  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmedul","family":"Kabir","sequence":"additional","affiliation":[{"name":"AMZ Hospital Ltd.  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0935-8079","authenticated-orcid":false,"given":"Zhahirul","family":"Islam","sequence":"additional","affiliation":[{"name":"Gut\u2010Brain Axis Laboratory, Infectious Diseases Division, icddr,b  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-025-24009-z"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-023-01430-z"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i3.424"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v31.i9.100221"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30333-4"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/1319-3767.49012"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.14.04107"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/gidisord6020038"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2021.07.037"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030815"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000002164"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1999.00026.x"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i12.3146"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare13020128"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjsopen\/zrad098"},{"issue":"4","key":"e_1_2_15_17_1","first-page":"181","article-title":"Management of Anal Fistulas in Crohn's Disease After Failure of Infliximab","volume":"102","author":"Ben Azouz S.","year":"2024","journal-title":"La Tunisie M\u00e9dicale"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.5402\/2011\/672017"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73049","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.73049","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T05:35:43Z","timestamp":1787117743000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.73049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/ccr3.73049"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.73049","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,29]]},"assertion":[{"value":"2025-11-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e73049"}}