{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:25:46Z","timestamp":1787120746094,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Brain abscess is an uncommon but life\u2010threatening intracranial infection that most often arises from contiguous spread but may also occur through hematogenous dissemination in patients with congenital heart disease. This is usually associated with defects that permit right\u2010to\u2010left shunting of septic emboli. Its occurrence in association with atrioventricular septal defect (AVSD) is rarely reported, particularly as the initial presentation in adulthood. We report an 18\u2010year\u2010old male who presented with a generalized tonic\u2013clonic seizure preceded by a 4\u2010day history of frontal headache. Examination revealed digital clubbing, conjunctival plethora, and a pansystolic murmur. Neuroimaging demonstrated a right frontal lobe abscess. Cardiac evaluation identified atrial flutter and a previously undiagnosed AVSD with a large atrial component resulting in a common atrium and a ventricular component with predominantly left\u2010to\u2010right shunting, without echocardiographic evidence of pulmonary hypertension. The patient recovered fully with complete radiological resolution after surgical drainage of the abscess, and remained clinically stable at 6\u2010month follow\u2010up. In patients with AVSD and a common atrium, the absence of atrial septation due to the large atrial component permits mixing of systemic and pulmonary venous blood that may result in chronic hypoxemia. This intracardiac communication may also allow septic material to bypass pulmonary clearance. Brain abscess may therefore represent the initial manifestation of AVSD with a common atrium, highlighting the importance of careful cardiovascular examination and timely echocardiographic evaluation in patients presenting with a brain abscess of unclear origin.<\/jats:p>","DOI":"10.1002\/ccr3.73057","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T03:34:54Z","timestamp":1782704094000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brain Abscess Revealing an Undiagnosed Atrioventricular Septal Defect With a Common Atrium in a Young Adult"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8521-1821","authenticated-orcid":false,"given":"Evans Nii Ayitey","family":"MacCready","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Cape Coast Teaching Hospital  Cape Coast Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ama Owusuaa","family":"Kwakye","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cape Coast Teaching Hospital  Cape Coast Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin","family":"Denanyoh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cape Coast Teaching Hospital  Cape Coast Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilda","family":"Kwapong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cape Coast Teaching Hospital  Cape Coast Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac Nene","family":"Keteku","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cape Coast Teaching Hospital  Cape Coast Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochebed","family":"Ansah","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cape Coast Teaching Hospital  Cape Coast Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werman Reve","family":"Robles","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cape Coast Teaching Hospital  Cape Coast Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1301635"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02860506"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.1.4.593"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e22198"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886\u2010021\u201001523\u20101"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd8020019"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild\u20102019\u2010epa.841"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951119001288"},{"issue":"5","key":"e_1_2_12_10_1","first-page":"403","article-title":"A Brain Abscess of Probable Odontogenic Origin in a Child With 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