{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:25:44Z","timestamp":1787120744534,"version":"build-2736575974"},"reference-count":9,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Baclofen, a GABA_B receptor agonist, is increasingly linked to misuse and severe withdrawal symptoms, including acute neuropsychiatric manifestations. We present a 26\u2010year\u2010old male exhibiting severe substance use disorder and recurrent depressive episodes, accompanied by profound insomnia, suicidal ideation, and visual hallucinations. He had been taking baclofen in high doses (200\u2009mg\/day) for 2\u20133\u2009years, and he was still using cocaine and opioids from time to time. There was no acute intoxication, and the lab tests and electrocardiography were normal. It was thought that he was going through baclofen withdrawal, so he was given lorazepam 2\u2009mg, which was slowly reduced over 2\u2009weeks, leading to clinical stabilization. This case emphasizes baclofen withdrawal as a potentially fatal factor in psychiatric decline and underscores the necessity for prompt identification, meticulous observation, and tailored intervention particularly in patients with psychiatric disorders and comorbid substance use.<\/jats:p>","DOI":"10.1002\/ccr3.73067","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T03:33:26Z","timestamp":1782704006000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Baclofen Misuse in Clinical Practice: A Case Report on Management Strategies"],"prefix":"10.1002","volume":"14","author":[{"given":"Mostafa","family":"Yousef","sequence":"first","affiliation":[{"name":"Department of Psychiatry Karl Jaspers Klinik  Bad Zwischenahn DEU Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Elsayed","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy III University of Ulm  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0649-6310","authenticated-orcid":false,"given":"Ahmed Hosney","family":"Nada","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Benha University  Benha Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0692-9027","authenticated-orcid":false,"given":"Olivier","family":"Uwishema","sequence":"additional","affiliation":[{"name":"Department of Research and Education Oli Health Magazine Organization  Kigali Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425787"},{"key":"e_1_2_12_3_1","volume-title":"Lexicon of Alcohol and Drug Terms [Internet]","author":"World Health Organization","year":"1994"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215\u20100366(16)00104\u20108"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1511480"},{"key":"e_1_2_12_6_1","volume-title":"Facing Addiction in America: The Surgeon General's Report on Alcohol, Drugs, and Health","author":"U.S. Department of Health and Human Services","year":"2016"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/apmr.2002.32820"},{"key":"e_1_2_12_8_1","volume-title":"Lorazepam","author":"Ghiasi N.","year":"2025"},{"key":"e_1_2_12_9_1","volume-title":"Benzodiazepines","author":"Bounds C. G.","year":"2025"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004867418808897"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.73067","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T05:34:48Z","timestamp":1787117688000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.73067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,28]]},"references-count":9,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/ccr3.73067"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.73067","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,28]]},"assertion":[{"value":"2026-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e73067"}}