{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:06:33Z","timestamp":1783209993010,"version":"3.54.6"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>In this case of struma ovarii a right\u2010sided ovarian mass contained features of papillary thyroid cancer. Diagnostic iodine\u2010123 revealed multiple foci of extraovarian spread, likely as a manifestation of concomitant peritoneal strumosis. Unilateral oophorectomy, partial peritonectomy, and adjuvant iodine\u2010131 treatment were performed for successful curative treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Struma ovarii is a rare form of mature teratoma defined by a predominance of thyroid tissue. Approximately 5% of all ovarian strumae exhibit malignant transformation. Due to their extreme rarity, there has been a lack of consensus concerning uniform diagnostic criteria. Appropriate, risk\u2010stratified treatment strategies also remain widely unelaborated, based only on a small number of cases reported in the literature. We describe the case of a 35\u2010year\u2010old female, who presented after undergoing unilateral oophorectomy for a right\u2010sided ovarian mass. Histological workup revealed a struma ovarii containing papillary thyroid cancer (PTC). Postoperative I\u2010123 scintigraphy with single photon emission computed tomography (SPECT) detected multifocal extra\u2010ovarian spread to the peritoneum, containing likely benign strumosis upon pathological examination. The subsequent treatment strategy involved an ablative concept including total thyroidectomy and subsequent I\u2010131 radioiodine therapy. Throughout a 3\u2010year follow\u2010up, the patient has remained without recurrence with thyroglobulin levels ranging below detection limits. Surgical resection with adjuvant radioiodine therapy is a curative therapeutic strategy in cases of struma ovarii with thyroid\u2010type carcinoma and peritoneal strumosis. Its benefits lay in avoiding more extensive surgery, potentially maintaining fertility, facilitating follow\u2010up, and minimizing the risk of recurrence. Reliable criteria for risk stratification are needed to identify patients who are most likely to benefit from this treatment approach.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.7311","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T04:36:07Z","timestamp":1683261367000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Thyroid papillary cancer elements arising from struma ovarii with benign peritoneal strumosis: Utility of iodine\u2010123 imaging in diagnostics and treatment planning"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7927-6226","authenticated-orcid":false,"given":"Daniel","family":"Groener","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine University Hospital Frankfurt  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justus","family":"Baumgarten","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital Frankfurt  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Happel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital Frankfurt  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolai","family":"Mader","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital Frankfurt  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina Nguyen","family":"Ngoc","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital Frankfurt  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Sabet","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital Frankfurt  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Gr\u00fcnwald","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital Frankfurt  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"134","article-title":"Beitrag zur Lehre von den Geschw\u00fclsten. \u00dcber strumathyreoidea ovarii aberrata","volume":"33","author":"Pick L","year":"1903","journal-title":"Verh Berlin Med 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ovarii: report of a case and review of the literature","volume":"58","author":"Kostoglou\u2010Athanassiou I","year":"2002","journal-title":"Horm Res"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01736995"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/105072501316973163"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199404000-00012"}],"container-title":["Clinical Case 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