{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T09:44:58Z","timestamp":1791798298057,"version":"4.3.4"},"reference-count":10,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic Lymphocytic Leukemia (CLL) and Chronic Myeloid Leukemia (CML) are two distinct hematological malignancies with different pathophysiologies and clinical courses. While each is relatively common in the elderly population, their simultaneous occurrence in a single patient is exceptionally rare and poses diagnostic and therapeutic challenges. We present the case of a 79\u2010year\u2010old male who was evaluated for progressive fatigue, weight loss, and marked leukocytosis. Laboratory investigations, peripheral blood smear, flow cytometry, and molecular studies were utilized to establish the diagnosis. Initial findings revealed extreme leukocytosis, anemia, and elevated LDH. Peripheral smear and molecular testing confirmed CML through detection of the\n                    <jats:italic>BCR::ABL1<\/jats:italic>\n                    fusion gene. Concurrently, flow cytometry identified a clonal B\u2010cell population positive for CD5, CD19, and CD20, consistent with CLL. Imaging showed splenomegaly and pathologic lymphadenopathy. The patient was treated with imatinib and hydroxyurea, resulting in normalization of white blood cell count, though anemia and thrombocytopenia persisted. This case highlights a rare synchronous diagnosis of CML and CLL in an elderly patient. The comprehensive diagnostic evaluation was critical in establishing the dual pathology. The case underscores the need for heightened clinical suspicion in atypical presentations and contributes to the limited body of knowledge on coexistent myeloid and lymphoid malignancies.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.73136","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T08:47:38Z","timestamp":1791794858000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Rare Case of Chronic Lymphocytic Leukemia and Chronic Myeloid Leukemia in an Elderly Patient: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4030-3850","authenticated-orcid":false,"given":"Mostafa","family":"Kamandi","sequence":"first","affiliation":[{"name":"Hematologist\u2010Oncologist, Department of Internal Medicine, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6432-8748","authenticated-orcid":false,"given":"Mohammad Mahdi","family":"Alvandi Fard","sequence":"additional","affiliation":[{"name":"Student Research Committee, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"iv41","DOI":"10.1093\/annonc\/mdx219","article-title":"Chronic Myeloid Leukaemia: ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow\u2010Up","volume":"28","author":"Hochhaus A.","year":"2017","journal-title":"Annals of Oncology"},{"issue":"10129","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/S0140-6736(18)30422-7","article-title":"Chronic Lymphocytic Leukaemia","volume":"391","author":"Hallek M.","year":"2018","journal-title":"Lancet"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.critrevonc.2016.06.003","article-title":"Chronic Lymphocytic Leukaemia","volume":"104","author":"Scarf\u00f2 L.","year":"2016","journal-title":"Critical Reviews in Oncology\/Hematology"},{"issue":"1","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"6805","DOI":"10.1182\/blood-2024-205929","article-title":"Review of Rare Association Between Chronic Lymphocytic Leukemia and Chromic Myeloid Leukemia","volume":"144","author":"Abdalla E.","year":"2024","journal-title":"Blood"},{"issue":"20","key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"5279","DOI":"10.1182\/blood-2010-08-301788","article-title":"Simultaneous Chronic Myeloid Leukemia and Chronic Lymphocytic Leukemia","volume":"117","year":"2011","journal-title":"Blood"},{"issue":"4","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","DOI":"10.12890\/2024_004297","article-title":"A Rare Case of an Elderly Male With Progression to Chronic Myeloid Leukaemia Secondary to Chronic Lymphocytic Leukaemia","volume":"11","author":"Saowapa S.","year":"2024","journal-title":"European Journal of Case Reports in Internal Medicine"},{"issue":"3","key":"e_1_2_9_8_1","first-page":"EPR23","article-title":"EPR23\u2010077: Incidence and Mechanisms of Coexisting Hematological Malignancies: Chronic Lymphocytic Leukemia and Chronic Myeloid Leukemia\u2014A Retrospective Review","volume":"21","author":"Badal S.","year":"2023","journal-title":"Journal of the National Comprehensive Cancer Network"},{"issue":"6","key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1002\/1097-0142(19930315)71:6<1993::AID-CNCR2820710612>3.0.CO;2-6","article-title":"Simultaneous Chronic Lymphocytic Leukemia and Chronic Myelogenous Leukemia. Evidence of a Separate Stem Cell Origin","volume":"71","author":"Maher V. E.","year":"1993","journal-title":"Cancer"},{"issue":"1","key":"e_1_2_9_10_1","article-title":"Progression From Chronic Myeloid Leukemia to Chronic Lymphocytic Leukemia: A Rare Case","volume":"9","author":"Shirinova A.","year":"2024","journal-title":"Annals of Clinical Case Reports"},{"issue":"4","key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.4103\/0377-4929.125369","article-title":"Simultaneous Occurrence of Chronic Myeloid Leukemia and Chronic Lymphocytic Leukemia: Report of an Unusual Case","volume":"56","author":"Rahman K.","year":"2013","journal-title":"Indian Journal of Pathology & Microbiology"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73136","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.73136","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T08:47:39Z","timestamp":1791794859000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.73136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/ccr3.73136"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.73136","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.175993433.33308968\/v1","asserted-by":"object"}]},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2025-10-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e73136"}}