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In adolescents with hypergonadotropic hypogonadism, prompt karyotype analysis is essential to identify 46,XY complete gonadal dysgenesis (Swyer syndrome), enabling timely prophylactic gonadectomy, preventing gonadal malignancy, and improving endocrine, reproductive, and long\u2010term clinical outcomes.<\/jats:p>","DOI":"10.1002\/ccr3.73154","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T04:19:50Z","timestamp":1783916390000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stage\n                    <scp>IIIC<\/scp>\n                    Bilateral Dysgerminoma in 46,\n                    <scp>XY<\/scp>\n                    Swyer Syndrome: Preventing Malignancy Through Early Endocrine Evaluation of Primary Amenorrhea"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0249-1865","authenticated-orcid":false,"given":"Chukwuka","family":"Elendu","sequence":"first","affiliation":[{"name":"Federal University Teaching Hospital  Owerri Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5352-3248","authenticated-orcid":false,"given":"Alamjeet K.","family":"Sidhu","sequence":"additional","affiliation":[{"name":"Connecticut Institute for Communities  Danbury USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8119-1211","authenticated-orcid":false,"given":"Olisa S.","family":"Okabekwa","sequence":"additional","affiliation":[{"name":"University of Nigeria Teaching Hospital  Enugu Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayi T.","family":"Debua","sequence":"additional","affiliation":[{"name":"University of Calabar Teaching Hospital  Calabar Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed I.","family":"Ali","sequence":"additional","affiliation":[{"name":"Medical Academy Named After S.I. 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