{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:26:01Z","timestamp":1787120761725,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Sertoli cell tumors are uncommon sex\u2010cord stromal tumors making up &lt;\u20092% of testicular tumors and have been reported to be associated with endocrine dysfunction that could compromise male fertility. Herein, we present a 34\u2010year\u2010old Pakistani male with primary infertility, azoospermia, enlargement of right testis, and contralateral severe testicular atrophy. Hormone analysis showed decreased testosterone level, high follicle\u2010stimulating hormone, and high levels of estradiol with normal levels of serum tumor markers. Ultrasonography and computed tomography revealed a right intratesticular well\u2010defined mass with severe testicular atrophy of the left testis. Right radical orchidectomy was done. Histopathology revealed benign NOS\u2010type Sertoli cell tumor with positive staining for vimentin and calretinin. Non\u2010tumorous testicular parenchyma showed severe impairment in spermatogenesis with Johnsen score 2\u20133. After the procedure, normalizing hormones were observed but azoospermia persisted. Our report underscores the occurrence of contralateral testicular atrophy with azoospermia due to a unilateral Sertoli cell tumor probably due to chronic estrogen elevation. Evaluation of patients with Sertoli cell tumors for endocrine disorders, fertility assessments, and discussion of fertility preservation measures including onco\u2010testicular sperm extraction needs to be considered.<\/jats:p>","DOI":"10.1002\/ccr3.73193","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:43:58Z","timestamp":1784717038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Azoospermia, Atrophy, and Asymmetry: Unilateral Sertoli Cell Tumor as a Rare and Overlooked Cause of Male Infertility: A Case Report and Literature Review"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8791-9583","authenticated-orcid":false,"given":"Rao Nouman","family":"Ali","sequence":"first","affiliation":[{"name":"District Headquarters Hospital  Khanewal 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