{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:19:26Z","timestamp":1790983166982,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ceftazidime\/avibactam (CAZ\u2010AVI) is an important therapeutic option for multidrug\u2010resistant (MDR)\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    <\/jats:styled-content>\n                    infections; however, hypersensitivity reactions may preclude its use and create significant therapeutic challenges. We report a 21\u2010year\u2010old woman with cystic fibrosis and recurrent MDR\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                    <\/jats:styled-content>\n                    pneumonia who had a clinically suspected immediate hypersensitivity reaction to CAZ\u2010AVI. In the absence of effective alternative antimicrobial options, a 13\u2010step rapid intravenous desensitization protocol was performed under intensive monitoring. The patient subsequently tolerated full\u2010dose CAZ\u2010AVI therapy with marked clinical improvement. Rapid desensitization may represent an effective rescue strategy for patients with CAZ\u2010AVI allergy when applied under strict clinical indications and multidisciplinary supervision.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.73208","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:01:27Z","timestamp":1785841287000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Successful Rapid Desensitization to Ceftazidime\/Avibactam in a Patient With Cystic Fibrosis and Multidrug\u2010Resistant\n                    <scp>\n                      <i>Pseudomonas aeruginosa<\/i>\n                    <\/scp>\n                    Pneumonia: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7466-9309","authenticated-orcid":false,"given":"Zuoren","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinqi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00576-6"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-00477-5"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00913"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(22)00329-9"},{"issue":"3","key":"e_1_2_13_6_1","first-page":"e27","article-title":"Mortality Attributable to Carbapenem\u2010Resistant \n                     Pseudomonas aeruginosa\n                   Bacteremia: A Meta\u2010Analysis of Cohort Studies","volume":"5","author":"Zhang Y.","year":"2016","journal-title":"Emerging Microbes & Infections"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-018-0902-x"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00031-19"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2022.100640"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.631221"},{"issue":"2","key":"e_1_2_13_11_1","first-page":"94","article-title":"Rapid Desensitization After a Type I Hypersensitivity Reaction to Ceftazidime\/Avibactam","volume":"39","author":"Coop C. 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