{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:25:20Z","timestamp":1787120720147,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Gitelman syndrome (GS), also known as familial hypokalaemia\u2010hypomagnesemia, is a rare autosomal recessive renal tubular disorder characterized by hypokalaemia, hypomagnesemia, metabolic alkalosis, and hypocalciuria. Electrolyte replacement of potassium and magnesium remains the mainstay of management, with oral supplementation achieving this in the majority of patients. We report the case of a 65\u2010year\u2010old woman with a severe manifestation of GS, managed with high\u2010dose intravenous electrolyte replacement as part of a home parenteral support (HPS) regimen in addition to oral supplementation. Initiation of HPS, whilst life\u2010saving and life\u2010prolonging, also negatively impacted her quality of life and was complicated by multiple catheter\u2010related bloodstream infections (CRBSI) and catheter\u2010related venous thromboses (CRVT). After 15\u2009years of HPS, her management was transitioned to a shared care model under an accredited multidisciplinary intestinal failure (IF) unit. Her significant parenteral electrolyte requirement was subsequently rationalized, and provision of compounded home infusions reduced her treatment burden by allowing her to sleep through each night without additional connections and disconnections. No further episodes of CRBSIs occurred, and no further venous catheter exchanges were necessary. In this case report, we illustrate the presentation of severe GS, highlight the necessity of daily intravenous electrolyte replacement in such cases, and emphasize how collaborative management between nephrology and teams experienced in long\u2010term catheter care can be crucial in optimizing treatment, improving patient outcomes, and enhancing quality of life.<\/jats:p>","DOI":"10.1002\/ccr3.73210","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T09:22:11Z","timestamp":1784712131000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Home Parenteral Support in Severe Gitelman Syndrome: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4407-4787","authenticated-orcid":false,"given":"Georgia","family":"Martin","sequence":"first","affiliation":[{"name":"Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Fahal","sequence":"additional","affiliation":[{"name":"Department of Nephrology Barking Havering and Redbridge University Hospitals NHS Trust  Romford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7002-293X","authenticated-orcid":false,"given":"Shameer","family":"Mehta","sequence":"additional","affiliation":[{"name":"Queen Mary University of London  London UK"},{"name":"Department of Gastroenterology Barts Health NHS Trust  London 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