{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:07:43Z","timestamp":1753862863904,"version":"3.41.2"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>Myeloma of the thyroid cartilage is a rare but important differential diagnosis of a laryngeal mass. Although hoarseness as the initial presenting symptom in multiple myeloma is extremely rare, a clinician should always consider it.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Multiple myeloma (MM) is a malignant plasma cell disorder characterized by an uncontrolled proliferation of monoclonal plasma cells. Although the clinical presentation at diagnosis can be quite variable, thyroid cartilage infiltration in MM is rare. Here we discuss a 65\u2010year\u2010old Caucasian male presenting to the ENT doctor with continuous hoarseness for 3\u2009months. The initial clinical examination showed a tangible mass at the left lymph node level II\u2013III. Further examination with fiber\u2010optic laryngoscopy showed a bulging of the aryepiglottic and ventricular fold. Neck and chest CT scan revealed multiple osteolytic bone lesions in addition to the large lesion in the left thyroid cartilage. Laboratory work\u2010up, PET\u2010CT scan and biopsy of the thyroid cartilage were performed and eventually all confirmed the presence of a new diagnosis of IgA kappa MM. The patient was referred to the department of hematology to start with chemotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.7322","type":"journal-article","created":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T03:24:01Z","timestamp":1683948241000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hoarseness as the initial presentation of multiple myeloma"],"prefix":"10.1002","volume":"11","author":[{"given":"Jules","family":"Colebunders","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences University of Antwerp  Wilrijk Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stig","family":"Hellemans","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences University of Antwerp  Wilrijk Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melek","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Antwerp University Hospital  Edegem Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasha","family":"Libbrecht","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Antwerp University Hospital  Edegem Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9v\u00e9rine","family":"de Bruijn","sequence":"additional","affiliation":[{"name":"Department of Haematology Antwerp University Hospital  Edegem Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2016.0470"},{"issue":"8","key":"e_1_2_9_3_1","first-page":"338","article-title":"Guidelines of the Belgian hematology society for imaging in multiple myeloma","volume":"12","author":"Meuleman N","year":"2021","journal-title":"Belg J Hematol"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00135-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-270140"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70442-5"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-017-0549-1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4065\/78.1.21"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-631200"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-022-00643-3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijmpo.ijmpo_43_16"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-011-0097-z"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004050100399"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.123045"},{"key":"e_1_2_9_15_1","first-page":"316","article-title":"Multiple myeloma involving the thyroid cartilage: case report","volume":"23","author":"Sosna J","year":"2022","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_9_16_1","first-page":"570","article-title":"Multiple myeloma involving the thyroid cartilage","volume":"17","author":"Van Dyke CW","year":"1996","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0145561319861379"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.7322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T08:46:30Z","timestamp":1692434790000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.7322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1002\/ccr3.7322"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.7322","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"2023-03-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e7322"}}