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This case series presents three cases of methanol poisoning: two patients with neurological symptoms and unexplained high anion gap metabolic acidosis were initially misdiagnosed as stroke or diabetic ketoacidosis and died after transfer, whereas the third patient received prompt empirical hemodialysis based on clinical suspicion and survived with full recovery. These cases illustrate that early recognition and empirical hemodialysis guided by clinical judgment, without confirmatory toxicology testing, can be life\u2010saving in resource\u2010constrained environments.<\/jats:p>","DOI":"10.1002\/ccr3.73220","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:20:36Z","timestamp":1785471636000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Challenges of Methanol Poisoning in Resource\u2010Limited Settings: A Case Series"],"prefix":"10.1002","volume":"14","author":[{"given":"Hongyun","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine People's Hospital of Anshun  Anshun Guizhou 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