{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T06:14:20Z","timestamp":1788156860872,"version":"build-2803163510"},"reference-count":5,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Pan\u2010drug resistant\n \n Klebsiella pneumoniae<\/jats:italic>\n <\/jats:styled-content>\n is a major therapeutic challenge, particularly when standard last\u2010line agents are unavailable or contraindicated. We report a 45\u2010year\u2010old man with multifocal osteomyelitis and persistent purulent wound discharge despite broad\u2010spectrum antibiotics, repeated debridement, and two sequential amputations. Wound culture grew\n \n K. pneumoniae<\/jats:italic>\n <\/jats:styled-content>\n resistant to all antibiotics tested in the locally available susceptibility panel. Initial treatment with colistin plus extended\u2010infusion meropenem was discontinued because of acute kidney injury. Oral doxycycline 100\u2009mg twice daily combined with rifampin 600\u2009mg once daily was then initiated as salvage therapy, resulting in rapid resolution of purulent discharge and marked reduction in inflammatory markers. This case suggests that oral doxycycline plus rifampin may represent a low\u2010cost and accessible salvage option for highly resistant\n \n K. pneumoniae<\/jats:italic>\n <\/jats:styled-content>\n infections when standard therapies are unavailable or not tolerated.\n <\/jats:p>","DOI":"10.1002\/ccr3.73238","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T09:07:07Z","timestamp":1784970427000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Combination of Oral Doxycycline and Rifampin for Pan\u2010Drug Resistant\n Klebsiella pneumoniae<\/i>\n Infection: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"given":"Ali Akbar","family":"Heydari","sequence":"first","affiliation":[{"name":"Research Center for Infection Control & Hand Hygiene, Department of Infectious Diseases, Imam Reza Hospital Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9857-1175","authenticated-orcid":false,"given":"Sepideh","family":"Elyasi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7133-820X","authenticated-orcid":false,"given":"Farshad","family":"Abedi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,25]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9040196"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae403"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/jgid.jgid_34_23"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2009.08.011"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw213"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73238","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.73238","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:23:25Z","timestamp":1788153805000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.73238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,25]]},"references-count":5,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/ccr3.73238"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.73238","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,25]]},"assertion":[{"value":"2025-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e73238"}}