{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T06:14:19Z","timestamp":1788156859016,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Fibromyalgia (FM) is a chronic pain syndrome characterized by widespread musculoskeletal pain, often accompanied by fatigue, sleep disturbance, and cognitive symptoms. Although several treatment options are available, no curative therapy has been established. Histobulin is a histamine\u2010fixed immunoglobulin preparation developed to regulate serum histamine levels through histaminopexy. It has been reported to have therapeutic effects in allergic rhinitis, bronchial asthma, chronic urticaria, and atopic dermatitis. We report a patient with FM and concomitant chronic urticaria and allergic rhinitis who experienced improvement in FM after Histobulin therapy. A 39\u2010year\u2010old Korean woman presented with a 6\u2010year history of chronic urticaria, allergic rhinitis with rhinorrhea, and widespread musculoskeletal pain. She had previously been diagnosed with FM and had received oral treatment for pain for 13\u2009months. At the first visit, her widespread pain index (WPI) was 9 and her symptom severity scale (SSS) score was 12. Histobulin therapy was initiated primarily for chronic urticaria and allergic rhinitis. During treatment, she reported reductions in widespread pain, finger stiffness, and insomnia, as well as improved daily functioning and reduced use of rescue analgesics. After six injections, the patient reported marked reductions in FM symptoms and in symptoms of urticaria and rhinitis. No recurrence was reported during the subsequent 3\u2010week follow\u2010up period. FM symptoms improved after Histobulin therapy initiated for chronic urticaria and allergic rhinitis. This observation suggests that modulation of histamine\u2010related or immune pathways may be associated with clinical improvement. However, causality cannot be established from a single case report, and further controlled studies are required.<\/jats:p>","DOI":"10.1002\/ccr3.73248","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T05:02:13Z","timestamp":1786338133000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Improvement of Fibromyalgia by Immunoglobulin\/Histamine Complex Therapy for Chronic Urticaria and Allergic Rhinitis: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0566-0142","authenticated-orcid":false,"given":"Hyuk Soon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, College of Natural Science and Department of Health Sciences The Graduate School of Dong\u2010A University  Busan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5871-4326","authenticated-orcid":false,"given":"Yunyoung","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Cheju Halla General Hospital  Jeju\u2010si Jeju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5366-8368","authenticated-orcid":false,"given":"Jeong Eun","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Cheju Halla General Hospital  Jeju\u2010si Jeju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4083-6844","authenticated-orcid":false,"given":"Geunwoong","family":"Noh","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology Cheju Halla General Hospital  Jeju\u2010si Jeju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330203"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22083891"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2008.12.003"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138024"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.2015.1046841"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-016-0556-x"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X23500143"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrp.2011.07.003"},{"key":"e_1_2_13_10_1","first-page":"1","article-title":"Histaminopexy","volume":"17","author":"Rostafinska J.","year":"1964","journal-title":"Wiadomo\u015bci Lekarskie"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15381"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2016.08.012"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0037562"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60120-2"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21217877"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2018.07.009"},{"issue":"8","key":"e_1_2_13_17_1","first-page":"82","article-title":"Use of Histaglobulin in the Complex Treatment of Exacerbations of Chronic Gastritis","volume":"60","author":"Chernin V. 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