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Although generally safe, serious adverse effects may occur in selected patients, particularly when statins are used at high doses or without medical supervision. We describe a 66\u2010year\u2010old man with hypertension and hyperlipidemia who developed syncope after self\u2010adjusting atorvastatin from 20\u2009mg daily to 80\u2009mg daily for two weeks. On admission, electrocardiography showed sinus arrest with a ventricular escape rhythm, accompanied by acute hepatic and renal dysfunction, electrolyte abnormalities, coagulation abnormalities, and elevated inflammatory markers. Common reversible causes, including thyroid dysfunction, structural heart disease, acute myocarditis, Lyme disease, and the use of negative chronotropic drugs, were not supported by the clinical evaluation. After temporary pacing and supportive treatment, liver and kidney function, electrolytes, and coagulation function returned to normal; however, symptomatic sinus arrest persisted, and a permanent pacemaker was implanted. During follow\u2010up, the electrocardiogram showed recovery of sinus rhythm. Pacemaker interrogation at 1\u2009year showed a pacing burden of approximately 80% when the lower rate limit was programmed at 70 beats per minute; after the lower rate limit was reduced to 50 beats per minute, the pacing burden decreased to approximately 20% at the subsequent follow\u2010up. This finding suggests partial recovery of intrinsic sinus rhythm but persistent or intermittent sinus node dysfunction. The case supports a cautious interpretation of possible atorvastatin\u2010associated severe bradyarrhythmia mediated by multiorgan dysfunction rather than definitive direct statin\u2010induced sinus node injury. Clinicians should carefully educate patients not to self\u2010adjust statin doses and should monitor for serious adverse events when high\u2010dose statin exposure is suspected.<\/jats:p>","DOI":"10.1002\/ccr3.73270","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T03:59:22Z","timestamp":1785556762000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Atorvastatin\u2010Associated Severe Bradyarrhythmia Following Multiorgan Dysfunction: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0414-7716","authenticated-orcid":false,"given":"Xiao\u2010Qing","family":"Kou","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular Diseases Lanzhou First People's Hospital  Lanzhou Gansu Province China"},{"name":"The First School of Clinical Medicine of Lanzhou University  Lanzhou Gansu Province China"},{"name":"Department of 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