{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:55:14Z","timestamp":1791273314385,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Vaginal metastasis from colorectal cancer is extremely rare. We report the case of a 58\u2010year\u2010old postmenopausal woman with rectosigmoid adenocarcinoma and synchronous liver and vaginal metastases who initially presented with gastrointestinal symptoms followed by vaginal bleeding. The diagnosis was established through colonoscopy, biopsy, CT, MRI, and FDG PET\u2010CT. After 6\u2009cycles of FOLFOX chemotherapy, the liver metastases regressed, while the primary tumor and vaginal lesions progressed. She subsequently underwent pelvic exenteration with ileal conduit formation and right hepatectomy, followed by pulmonary metastasectomy and stereotactic body radiotherapy for subsequent lung metastases. At 41\u2009months of follow\u2010up from diagnosis, the patient remains alive with disease and has demonstrated a favorable response to multimodal therapy. This case highlights the importance of gynecological evaluation in female patients with colorectal cancer and demonstrates that aggressive multimodal management can achieve prolonged disease control.<\/jats:p>","DOI":"10.1002\/ccr3.73280","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:58:06Z","timestamp":1787983086000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synchronous Vaginal and Liver Metastases in Rectosigmoid Cancer: Case Report and Literature Review"],"prefix":"10.1002","volume":"14","author":[{"given":"Tamader","family":"Alyaarabi","sequence":"first","affiliation":[{"name":"Department of Surgery Hamad General Hospital  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmood","family":"Al\u2010Dhaheri","sequence":"additional","affiliation":[{"name":"Colorectal Surgery Unit, Department of Surgery Hamad General Hospital  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6089-240X","authenticated-orcid":false,"given":"Hamza A.","family":"Abdul\u2010Hafez","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine and Health Sciences An\u2010Najah National University  Nablus Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammar","family":"Aleter","sequence":"additional","affiliation":[{"name":"Colorectal Surgery Unit, Department of Surgery Hamad General Hospital  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noof","family":"Al Naimi","sequence":"additional","affiliation":[{"name":"Colorectal Surgery Unit, Department of Surgery Hamad General Hospital  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Kurer","sequence":"additional","affiliation":[{"name":"Colorectal Surgery Unit, Department of Surgery Hamad General Hospital  Doha Qatar"},{"name":"College of Medicine, QU Health, Qatar University  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Abunada","sequence":"additional","affiliation":[{"name":"Colorectal Surgery Unit, Department of Surgery Hamad General Hospital  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Toffaha","sequence":"additional","affiliation":[{"name":"Colorectal Surgery Unit, Department of Surgery Hamad General Hospital  Doha Qatar"},{"name":"College of Medicine, QU Health, Qatar University  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21395"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2011.0104"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585\u2010015\u20109719\u20100"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep29765"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1956.01280010173023"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.97.4.944"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02587036"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1987.tb01005.x"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313480106700216"},{"key":"e_1_2_14_11_1","first-page":"270","article-title":"True Vaginal Metastasis of Rectal Cancer","volume":"67","author":"Yagci G.","year":"2005","journal-title":"Indian Journal of Surgery"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-004-0734-x"},{"key":"e_1_2_14_13_1","first-page":"219","article-title":"Single Vaginal Metastasis From Cancer of the Right Colon: Case Report","volume":"7","author":"Costa S. 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