{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T06:14:04Z","timestamp":1788156844785,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Vertebral artery dissection (VAD) is a recognized cause of ischemic stroke, and current management relies on antithrombotic therapy that is not specifically directed at structural repair of the arterial wall. We report a man in his mid\u201050s who presented with a sudden, severe right occipital headache after a golf swing and had a history of a contralateral left VAD 16\u2009years earlier. High\u2010resolution vessel wall magnetic resonance imaging and angiography showed an acute, unruptured dissection of the right V4 segment with an intramural hematoma, and serial imaging documented progression of the true\u2010lumen stenosis before treatment. Because the lesion was progressing and stenting of the intracranial V4 segment carried a high risk of iatrogenic rupture, autologous bone marrow\u2013derived mesenchymal stem cells (MSCs) were administered as a well\u2010tolerated adjunct to continued antithrombotic therapy, in two systemic infusions at 8\u2009weeks and 10\u2009months after onset. The patient had an uneventful clinical course with no infusion\u2010related adverse events, and follow\u2010up imaging at 11\u2009months showed resorption of the intramural hematoma and restoration of a normal\u2010appearing lumen and wall. Because spontaneous healing of unruptured VAD cannot be excluded, this single, uncontrolled observation cannot establish that MSC therapy caused the recovery; nonetheless, the treatment was well\u2010tolerated and the favorable course warrants evaluation in adequately controlled studies before any therapeutic role of MSCs in VAD can be defined.<\/jats:p>","DOI":"10.1002\/ccr3.73284","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T04:26:59Z","timestamp":1786422419000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural Restoration of an Unruptured Vertebral Artery Dissection Following Autologous Mesenchymal Stem Cell Therapy: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3429-2853","authenticated-orcid":false,"given":"Hyungchang","family":"Kang","sequence":"first","affiliation":[{"name":"Dr. Kim's Stem Cell Clinic  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eung Jae","family":"Lee","sequence":"additional","affiliation":[{"name":"Greenhospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7268-0741","authenticated-orcid":false,"given":"Moon Hyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Dr. Kim's Stem Cell Clinic  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5186-3868","authenticated-orcid":false,"given":"Hyun Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"R&amp;D Center Pharmicell Co. 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