{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T06:14:12Z","timestamp":1788156852112,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Central precocious puberty (CPP) is an increasingly recognized endocrine comorbidity in girls with Williams syndrome (WS), but its diagnosis and management may be complicated by the short stature and atypical growth pattern associated with WS. We report two girls with genetically confirmed WS and CPP who showed different clinical presentations and treatment courses. Both patients presented with advanced pubertal development and markedly advanced bone age. In Case 1, pubertal growth acceleration was not readily apparent on standard population\u2010based growth charts but became evident when assessed using WS\u2010specific growth charts. Gonadotropin\u2010releasing hormone agonist (GnRHa) therapy initially achieved sustained pubertal suppression, but the improvement in predicted adult height (PAH) was limited. Recombinant human growth hormone (GH) was subsequently added, and PAH progressively increased. In Case 2, rapid progression from breast development to menstrual bleeding prompted early combined treatment with GnRHa and GH. During follow\u2010up, bone\u2010age advancement remained limited and PAH increased above the mid\u2010parental height, allowing planned discontinuation of GnRHa and continuation of GH. These cases highlight the value of WS\u2010specific growth charts for recognizing abnormal growth acceleration and support individualized treatment strategies guided by pubertal progression, bone age advancement, growth velocity, and serial PAH assessment.<\/jats:p>","DOI":"10.1002\/ccr3.73301","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T04:21:56Z","timestamp":1787372516000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Central Precocious Puberty in Williams Syndrome: Two Cases Illustrating Diagnostic Challenges and Individualized Management"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4470-7760","authenticated-orcid":false,"given":"Kangxiang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Child Healthcare Hunan Children's Hospital  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Child Healthcare Hunan Children's Hospital  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Hunan Children's Hospital  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Child Healthcare Hunan Children's Hospital  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology Hunan Children's Hospital  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.13620"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00276-z"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.036997"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0305000924000436"},{"issue":"7","key":"e_1_2_12_6_1","article-title":"Williams Syndrome and Agreement: The Case for Spanish Speakers","volume":"10","author":"Llull Febrer A.","year":"2025","journal-title":"Language"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000914"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.40"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.127280"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13353-020-00551-x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2023.11.009"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000588"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2016.21.1.15"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqac194"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73301","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.73301","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:22:33Z","timestamp":1788153753000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.73301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/ccr3.73301"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.73301","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2025-05-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e73301"}}