{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:54:51Z","timestamp":1791273291230,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2022\/06041\u20100"],"award-info":[{"award-number":["2022\/06041\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/00394\u20102"],"award-info":[{"award-number":["2020\/00394\u20102"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We report a rare case of cutaneous metastasis from oral squamous cell carcinoma (OSCC). The primary tumor showed low expression of Galanin, CD68, GALR2, and Collagen IV, with increased FOXP3 and Vimentin. Systemic analysis revealed reduced CD8\n                    <jats:sup>+<\/jats:sup>\n                    cells and increased Tregs. The patient died following aggressive disease progression.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.73315","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:28:51Z","timestamp":1788330531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Rare Case of Cutaneous Metastasis From Oral Squamous Cell Carcinoma (\n                    <scp>OSCC<\/scp>\n                    ) and the Possible Role of\n                    <scp>GALR2<\/scp>\n                    as a Biomarker: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2939-3501","authenticated-orcid":false,"given":"Ianny Brum","family":"Reis","sequence":"first","affiliation":[{"name":"Tumor Immunology Laboratory, Department of Diagnosis and Surgery S\u00e3o Paulo State University (UNESP), School of Dentistry  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena Moraes","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Tumor Immunology Laboratory, Department of Diagnosis and Surgery S\u00e3o Paulo State University (UNESP), School of Dentistry  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo Paschoal","family":"Ferrarezi","sequence":"additional","affiliation":[{"name":"Tumor Immunology Laboratory, Department of Diagnosis and Surgery S\u00e3o Paulo State University (UNESP), School of Dentistry  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie Aparecida Rodrigues","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Tumor Immunology Laboratory, Department of Diagnosis and Surgery S\u00e3o Paulo State University (UNESP), School of Dentistry  Araraquara S\u00e3o Paulo Brazil"},{"name":"Department of Oral and Maxillofacial Diseases, Clinicum, Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camyla Rodrigues","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Tumor Immunology Laboratory, Department of Diagnosis and Surgery S\u00e3o Paulo State University (UNESP), School of Dentistry  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8163-8978","authenticated-orcid":false,"given":"\u00c1lvaro Formoso","family":"Pelegrini","sequence":"additional","affiliation":[{"name":"Tumor Immunology Laboratory, Department of Diagnosis and Surgery S\u00e3o Paulo State University (UNESP), School of Dentistry  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldenora Maria Ximenes","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Tumor Immunology Laboratory, Department of Diagnosis and Surgery S\u00e3o Paulo State University (UNESP), School of Dentistry  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"de Freitas Porsani","sequence":"additional","affiliation":[{"name":"Santa Casa Foundation Hospital of Araraquara  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1vio Ferlin","family":"Arbex","sequence":"additional","affiliation":[{"name":"Santa Casa Foundation Hospital of Araraquara  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Rossa","family":"Junior","sequence":"additional","affiliation":[{"name":"Tumor Immunology Laboratory, Department of Diagnosis and Surgery S\u00e3o Paulo State University (UNESP), School of Dentistry  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41415-022-5166-x"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1018685"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00224-3"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.07.011"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01550-6"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912\u2010022\u201001249\u20105"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.5.613"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.4161\/sgtp.20413"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-13-0904"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7885"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12315"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.2362"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22577"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.06.046"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000055740"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2018.07.036"},{"issue":"1","key":"e_1_2_13_19_1","first-page":"86","article-title":"Metastatic Disease in Head & Neck Oncology","volume":"40","author":"Pisani P.","year":"2020","journal-title":"Acta Otorhinolaryngologica Italica"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3628"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010020\u20100134\u2010x"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1983.tb22208.x"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v6.i3.438"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.89"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005249"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2018-0317"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585\u2010021\u201010082\u20102"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520616666160520112622"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201011503\u20102"},{"issue":"1","key":"e_1_2_13_30_1","first-page":"73","article-title":"Macrophage\/Histiocytic Antigen CD68 Expression in Neoplastic and Reactive Lymph Nodes","volume":"49","author":"Mazur G.","year":"2004","journal-title":"Roczniki Akademii Medycznej w Bia\u0142ymstoku"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2015.01305"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01731"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489950181828"},{"key":"e_1_2_13_34_1","unstructured":"A.Bose T.Chakraborty K.Chakraborty S.Pal andR.Baral \u201cNeck Squamous \u6709\u7528.Pdf \u201d(2008)."},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12698"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3317-2"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-021-00631-y"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73315","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.73315","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:39:17Z","timestamp":1791272357000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.73315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/ccr3.73315"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.73315","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e73315"}}