{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:54:56Z","timestamp":1791273296714,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Sickle cell leg ulcers (SCLUs) are a chronic and debilitating complication of sickle cell disease (SCD), often associated with severe pain, impaired mobility, delayed healing, and recurrence. Their management remains challenging because ulcer formation and persistence are driven by multiple overlapping mechanisms, including hemolysis\u2010associated vasculopathy, microvascular dysfunction, chronic inflammation, venous disease, and local tissue hypoxia. Despite standard measures such as local wound care, compression therapy, infection control, analgesia, and optimization of SCD\u2010directed treatment, many ulcers remain refractory, and high\u2010quality evidence guiding treatment is limited. We report a 44\u2010year\u2010old man with homozygous SCD (HbSS) and chronic venous disease who developed a painful refractory medial malleolar ulcer that failed to improve with conventional management. Adjunctive hyperbaric oxygen therapy (HBOT) was administered alongside standard wound care and was well tolerated, with no treatment\u2010related adverse events. Two months after completion of therapy, the ulcer showed near\u2010complete healing, accompanied by complete pain resolution and restoration of normal ambulation. This case provides additional clinical evidence that HBOT may be feasible and potentially useful in selected patients with refractory SCLUs; however, causality cannot be established from a single case, and prospective evaluation is required.<\/jats:p>","DOI":"10.1002\/ccr3.73320","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:40:52Z","timestamp":1789533652000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adjunctive Hyperbaric Oxygen Therapy for a Refractory Sickle Cell\u2010Associated Leg Ulcer: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7531-0232","authenticated-orcid":false,"given":"Jamil","family":"Wafi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Hamad Medical Corporation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4454-5307","authenticated-orcid":false,"given":"Awni","family":"Alshurafa","sequence":"additional","affiliation":[{"name":"Department of Hematology Hamad Medical Corporation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1144-8076","authenticated-orcid":false,"given":"Mohamed A.","family":"Yassin","sequence":"additional","affiliation":[{"name":"Department of Hematology Hamad Medical Corporation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.10"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/PGPM.S391394"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23571"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129334\u2010200410000\u201000010"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008394.pub4"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2018.0918"},{"issue":"1","key":"e_1_2_13_8_1","first-page":"1","article-title":"Hyperbaric Oxygen Therapy in the Treatment of Sickle Cell Ulcers","volume":"6","author":"Rudge F. W.","year":"1991","journal-title":"Journal of Hyperbaric Medicine"},{"key":"e_1_2_13_9_1","first-page":"28","article-title":"Hyperbaric Oxygen in the Treatment of Malleolar Ulcer From Sickle Cell Anemia","volume":"8","author":"Espinosa Martinez E.","year":"1992","journal-title":"Revista Cubana de Hematolog\u00eda e Inmunolog\u00eda y Hemoterapia"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1171971"},{"issue":"4","key":"e_1_2_13_11_1","first-page":"571","article-title":"Case Report: Complete Coverage of Chronic Sickle Cell Leg Ulcer Using Hyperbaric Oxygen Therapy Combined With Skin Grafting","volume":"52","author":"Luhulla K.","year":"2025","journal-title":"Undersea & Hyperbaric Medicine"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/03630269.2026.2658568"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181fbe2bf"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2025.101298"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102024\u2010084825"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73320","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.73320","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:38:35Z","timestamp":1791272315000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.73320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":14,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/ccr3.73320"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.73320","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e73320"}}