{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T06:14:07Z","timestamp":1788156847867,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Severe aplastic anemia (SAA) is a serious medical condition that is characterized by its abrupt onset, rapid progression of the disease, and alarmingly high mortality rate, making it a significant concern in the field of hematology. Intensive immunosuppressive therapy (IST) is one of the primary therapeutic options; however, some SAA patients do not respond to initial IST treatment. For these patients, salvage treatment remains a significant challenge. Consequently, predicting the efficacy of IST for SAA at initial diagnosis and developing the optimal curative regimen could potentially enhance treatment outcomes. The concurrent presence of trisomy 8 and a BCL6 corepressor (\n                    <jats:italic>BCOR<\/jats:italic>\n                    ) mutation in SAA is uncommon and may independently predict the efficacy of IST. In this case report, we presented a SAA patient exhibiting both trisomy 8 and a\n                    <jats:italic>BCOR<\/jats:italic>\n                    mutation at diagnosis. The bone marrow (BM) aspirate showed hypocellular BM and the bone marrow biopsy revealed a severe hypocellular bone marrow (15% cellularity). The patient experienced rapid clinical improvement, evidenced by reduced transfusion requirements and a favorable response to IST. Approximately two year's post\u2010IST, a follow\u2010up biopsy indicated remission, with the volume of hematopoietic tissue increasing to 40%. Cytogenetic analysis showed a normal karyotype, and no\n                    <jats:italic>BCOR<\/jats:italic>\n                    mutation was detected by next\u2010generation sequencing (NGS). Complete blood cell count results also showed improvement. In conclusion, we are the first to report a rare case of SAA characterized by the simultaneous presence of chromosome 8 abnormality and\n                    <jats:italic>BCOR<\/jats:italic>\n                    mutation in detail, which may represent a new distinct entity in SAA.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.73321","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T09:56:20Z","timestamp":1786528580000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Favorable Response to Immunosuppressive Therapy in Severe Aplastic Anemia With Trisomy 8 and\n                    <scp>BCOR<\/scp>\n                    Mutation: Sustained Hematologic Response Despite Evolving Mutational Profile\u2014A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8640-7017","authenticated-orcid":false,"given":"Mengzhu","family":"Shen","sequence":"first","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Collaborative Innovation Center of Hematology Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wei","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Collaborative Innovation Center of Hematology Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Shao","sequence":"additional","affiliation":[{"name":"Beijing Qinghe Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cao","family":"Qin","sequence":"additional","affiliation":[{"name":"Beijing Qinghe Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Jia","sequence":"additional","affiliation":[{"name":"Beijing Qinghe Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Collaborative Innovation Center of Hematology Peking University  Beijing China"},{"name":"Beijing Qinghe Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1009-8024","authenticated-orcid":false,"given":"Jinsong","family":"Jia","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Collaborative Innovation Center of Hematology Peking University  Beijing China"},{"name":"Beijing Qinghe Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-010777"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13853"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-024-01021-x"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103975"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.278413"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2018.03.003"},{"key":"e_1_2_13_8_1","first-page":"881","article-title":"Guidelines for the Diagnosis and Management of Aplastic Anemia in China (2022)","volume":"43","author":"Red Blood Cell Disease Group CSoHCMA","year":"2022","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414799"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-574889"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06105.x"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12246"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13153"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2008.002329"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-019-01462-6"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8652(200103)66:3<167::AID-AJH1040>3.0.CO;2-R"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-10-607572"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.30"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2270"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lrr.2020.100196"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2009.02061.x"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000336815"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2018.1.457"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-179728"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2015.01.007"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.14.1810"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2018.10.008"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2016.12.006"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.101642"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.6.1385.1385"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73321","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.73321","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:21:48Z","timestamp":1788153708000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.73321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/ccr3.73321"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.73321","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-03-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e73321"}}