{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T06:14:22Z","timestamp":1788156862398,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A condition known as harlequin ichthyosis appears rarely, marked by intense abnormalities in skin development due to inherited changes in the ABCA12 gene. This leads to major issues with the outer layer of skin, forming hard, plate\u2010like coverings split by wide cracks. Features include turned\u2010out eyelids, lips pulled back, and stiff joints in arms and legs; survival rates at birth remain low because of complications. A baby boy born before full term showed clear signs matching this diagnosis immediately after delivery. Earlier scans during pregnancy, specifically in the last 3 months, revealed widespread thickened skin, abnormal eye positioning, an always\u2010open mouth, joint stiffness, and dense particles floating in the womb fluid. Following birth, thickened skin patches covered much of the newborn's body, accompanied by fused digits, fluid loss, and low body temperature. Within a moist environment inside an enclosed warmer, treatment unfolded through moisturizing agents, hydration via vein access, infection prevention with medication, alongside eye protection. Gene testing remained absent, blocked by cost\u2010related barriers. Awareness at onset, strong support during initial days, coordination across specialties\u2014these shaped progress, especially where tools and funds run short.<\/jats:p>","DOI":"10.1002\/ccr3.73357","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:55:58Z","timestamp":1787028958000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Harlequin Ichthyosis in a Preterm Neonate: A Rare Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9771-1339","authenticated-orcid":false,"given":"Tayyeb","family":"Ali","sequence":"first","affiliation":[{"name":"Gomal Medical College  Dera Ismail Khan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1800-1800","authenticated-orcid":false,"given":"Muhammad Hassaan","family":"Javaid","sequence":"additional","affiliation":[{"name":"Shifa College of Medicine  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8656-5049","authenticated-orcid":false,"given":"Muhammad Wajid","family":"Siddique","sequence":"additional","affiliation":[{"name":"Ameer\u2010ud\u2010din Medical College  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4424-7325","authenticated-orcid":false,"given":"Hanna Tsehay","family":"Abebe","sequence":"additional","affiliation":[{"name":"St.Paul Hospital Millennium Medical College  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9891-1305","authenticated-orcid":false,"given":"Israr","family":"Ul Haq","sequence":"additional","affiliation":[{"name":"Gomal Medical College  Dera Ismail Khan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7585-0040","authenticated-orcid":false,"given":"Ejaz","family":"Ali","sequence":"additional","affiliation":[{"name":"Chengde Medical University  Chengde China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5506-3218","authenticated-orcid":false,"given":"Zuhaib","family":"Ali","sequence":"additional","affiliation":[{"name":"Liaqat University of Medical and Health Sciences  Jamshoro Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8885-229X","authenticated-orcid":false,"given":"Nayab Ayub","family":"Afridi","sequence":"additional","affiliation":[{"name":"Khyber Girls Medical College  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5610-2869","authenticated-orcid":false,"given":"Munazza","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Khyber Girls Medical College  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"StatPearls","author":"Elkhatib A. 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