{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:23:52Z","timestamp":1791559432809,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Serpentine supravenous hyperpigmentation (SSH) is a rare dermatological complication of intravenous chemotherapy characterized by linear hyperpigmented streaks along superficial veins. Bullous SSH represents an exceptionally rare variant with only a few previously reported cases in the literature. We report the case of a 50\u2010year\u2010old woman with HER2\u2010positive breast cancer who developed bullous SSH 5\u2009days after her first cycle of TCHP (docetaxel, carboplatin, trastuzumab, pertuzumab) chemotherapy. The patient presented with linear erythematous streaks and small tense bullae along the infusion vein on her right forearm. Treatment with topical mometasone furoate 0.1% ointment resulted in complete resolution within 2\u2009weeks. Preventive strategies described for SSH include use of contralateral arm venous access, thorough saline flushing after chemotherapy infusion, consideration of central venous access when feasible, and, in selected cases, modification of the chemotherapy regimen. In our patient, subsequent chemotherapy cycles were administered using contralateral arm venous access with thorough saline flushing (same flushing protocol as Cycle 1), without recurrence of SSH. The patient completed all six planned cycles and subsequently achieved pathologic complete response. This case is the first to demonstrate that conservative management of bullous SSH with topical mometasone furoate, combined with contralateral venous access and thorough saline flushing, enables successful rechallenge and uninterrupted continuation of planned oncological treatment with pathologic complete response as the outcome.<\/jats:p>","DOI":"10.1002\/ccr3.73371","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T04:27:51Z","timestamp":1787372871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Successful Management and Treatment Rechallenge Following Docetaxel\u2010Induced Serpentine Supravenous Hyperpigmentation With Bullous Features: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8458-7280","authenticated-orcid":false,"given":"Gayathri R.","family":"Nair","sequence":"first","affiliation":[{"name":"Medical Oncology Department Chris O'brien Lifehouse  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Koutsis","sequence":"additional","affiliation":[{"name":"Department of Dermatology Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepali","family":"Poels","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Chris O'brien Lifehouse  Camperdown New South Wales Australia"},{"name":"Department of Surgery Royal Prince Alfred Hospital  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nita","family":"Agar","sequence":"additional","affiliation":[{"name":"Department of Dermatology Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Warrier","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Breast Surgery Chris O'brien Lifehouse  Sydney New South Wales Australia"},{"name":"Department of Surgery Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Kumar","sequence":"additional","affiliation":[{"name":"Medical Oncology Department Chris O'brien Lifehouse  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2016.2833"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2024.12.021"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403\u2010024\u201003057\u20102"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SMJ.0b013e3181ce0f5e"},{"key":"e_1_2_13_6_1","first-page":"1303","article-title":"Persistent Supravenous Hyperpigmentation After 5\u2010Fluorouracil","volume":"60","author":"Hrushesky W. J. M.","year":"1976","journal-title":"Cancer Treatment Reports"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.70294"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378\u20106323.156191"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2005.06633"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.5070\/D309M643S1"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806\u20104841.20153521"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20103083.2005.01088"},{"issue":"4","key":"e_1_2_13_13_1","first-page":"34","article-title":"Serpentine Supravenous Hyperpigmentation\u2010Badge of Courage in Fight Against Cancer","volume":"26","author":"Regmi S.","year":"2023","journal-title":"Journal of Medical Systems"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.17391"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2024.47.189.43001"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/1110\u20106530.207489"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.22146\/inajbcs.v56i2.13006"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.ijd_397_22"},{"key":"e_1_2_13_19_1","first-page":"5","article-title":"Unusual Tree Bark Like Skin Pigmentation Over Veins After 5\u2010Flourouracil Infusion With Spontaneous Resolution","volume":"1","author":"Koyyala V. P. B.","year":"2017","journal-title":"Journal of Medical Sciences"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/Pigmentinternational.Pigmentinternational_10_20"},{"issue":"2","key":"e_1_2_13_21_1","article-title":"Supravenous Serpiginous Hypermelanosis: Docetaxel Induced; A Rare Occurrence","volume":"5","author":"Rajagopalan R.","year":"2024","journal-title":"Journal of Clinical Images and Medical Case Reports"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.5348\/ijcri-2013-04-303-CI-12"},{"key":"e_1_2_13_23_1","first-page":"65","article-title":"Supravenous Hyperpigmentation in Association With CHOP Chemotherapy of a CD30 Ki\u2010l\u2010Positive Anaplastic Large\u2010Cell Lymphoma","volume":"191","author":"Schulte\u2010Huermann P.","year":"1995","journal-title":"Dermatology"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.1102"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12981"},{"key":"e_1_2_13_26_1","first-page":"1297","article-title":"Docetaxel\u2010Induced Supravenous Serpentine Dermatitis: A Case Report and Literature Review","volume":"101","author":"Chaiyakul S.","year":"2018","journal-title":"Journal of the Medical Association of Thailand"},{"issue":"4","key":"e_1_2_13_27_1","first-page":"20","article-title":"Serpentine Supravenous Hyperpigmentation Following Cisplatin and Pemetrexed Chemotherapy","volume":"99","author":"Noori M.","year":"2017","journal-title":"Cutis"},{"issue":"2","key":"e_1_2_13_28_1","first-page":"198","article-title":"A Case of Persistent Serpentine Supravenous Hyperpigmented Eruption Associated With Docetaxel","volume":"49","author":"Umemura S.","year":"2009","journal-title":"Japanese Journal of Lung Cancer"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.37047\/jos.2022-88125"},{"issue":"1","key":"e_1_2_13_30_1","first-page":"33","article-title":"A Case of Supravenous Serpentine Dermatitis Associated With ONE TAXOTERE","volume":"54","author":"Miyamoto M.","year":"2014","journal-title":"Japanese Journal of Lung Cancer"},{"key":"e_1_2_13_31_1","article-title":"Serpentine Supravenous Eruption Docetaxel Related Diagnosed by Teledermatology","volume":"4","author":"P\u00e9rez N.","year":"2020","journal-title":"International Archives of Internal Medicine"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.72459"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2014-206793"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMicm0911228"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.01.127"},{"issue":"40","key":"e_1_2_13_36_1","first-page":"83","article-title":"Serpentine Supra\u2010Venous Hyperpigmentation \u201cBadge of Courage\u201d in Fight Against Cancer: An Brief Review","volume":"1","author":"Narayan S.","year":"2022","journal-title":"Gulf Journal of Oncology"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70361-5"},{"issue":"1","key":"e_1_2_13_38_1","first-page":"97","article-title":"Chemotherapy\u2010Induced Persistent Serpentine Supravenous Hyperpigmented Eruption and Persistent Supravenous Erythematous Eruption: Case Report","volume":"144","author":"Marongiu P.","year":"2009","journal-title":"Giornale Italiano di Dermatologia e Venereologia"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.106239"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMicm2207158"},{"issue":"1","key":"e_1_2_13_41_1","first-page":"1","article-title":"Serpentine Supravenous Hyperpigmentation in an HIV Patient Receiving R\u2010CHOP for DLBCL","volume":"12","author":"Lancman G.","year":"2018","journal-title":"International Journal of Hematology\u2010Oncology and Stem Cell Research"},{"issue":"6","key":"e_1_2_13_42_1","first-page":"381","article-title":"A Case of Persistent Serpentine Supravenous Hyperpigmented Eruption Associated With Repeated Intravenous Antineoplastic Therapy","volume":"5","author":"Sarayama Y.","year":"2006","journal-title":"Skin Research"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102133.2000.03518.x"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2008.08438.x"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190\u20109622(91)70280\u2010f"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468\u20103083.2002.00424.x"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12405"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247152"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.31031\/AICS.2020.02.000550"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1159\/000246423"},{"issue":"3","key":"e_1_2_13_51_1","first-page":"245","article-title":"Comparative Safety and Efficacy of Topical Mometasone Furoate With Other Topical Corticosteroids","volume":"29","author":"Spada F.","year":"2018","journal-title":"Journal of Dermatological Treatment"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73371","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.73371","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:22:41Z","timestamp":1788153761000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.73371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/ccr3.73371"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.73371","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e73371"}}