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We report acetaminophen\u2010induced acute liver failure with cerebral edema and active multifocal hemorrhage successfully managed with emergent liver transplantation and staged neurosurgical intervention. This case supports individualized transplantation when hepatic prognosis is fatal and neurologic recovery remains plausible.<\/jats:p>","DOI":"10.1002\/ccr3.73432","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:05:50Z","timestamp":1788411950000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Liver Transplantation Despite Active Intracranial Hemorrhage in Acetaminophen\u2010Induced Acute Liver Failure: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"given":"Daryna","family":"Shnitser","sequence":"first","affiliation":[{"name":"University of South Carolina School of Medicine  Greenville USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1241-4580","authenticated-orcid":false,"given":"Eslam","family":"Fouda","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Miami, Jackson Memorial Hospital  Miami USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramona","family":"Nicolau\u2010Raducu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Miami, Jackson Memorial Hospital  Miami USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0895-5496","authenticated-orcid":false,"given":"Fouad G.","family":"Souki","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Miami, Jackson Memorial Hospital  Miami USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91736-6"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20703"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-42641"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1208937"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25551"},{"key":"e_1_2_12_7_1","first-page":"1","article-title":"Management of Acute Liver Failure: Update 2022","volume":"42","author":"Stravitz R. 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