{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:54:48Z","timestamp":1791273288003,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Post\u2010traumatic hiccups are an uncommon but distressing complication of traumatic brain injury (TBI), often resistant to conventional pharmacological agents, and the underlying mechanism may involve central neurological disruption of inhibitory pathways rather than gastrointestinal or metabolic aetiologies. We report a male patient in his early 30s who developed refractory hiccups following moderate TBI sustained in a high\u2010impact motor vehicle collision; standard agents including chlorpromazine, metoclopramide, and haloperidol provided no meaningful relief after 48\u2009h of combined treatment. Intravenous levetiracetam (1000\u2009mg loading dose followed by 500\u2009mg every 12\u2009h) was initiated on hospital Day 6, which was followed by complete resolution of hiccups within 8\u2009h; the patient was discharged on hospital Day 7 without recurrence and remained symptom\u2010free at two\u2010week outpatient follow\u2010up. This case highlights levetiracetam as a promising rescue therapy for post\u2010TBI hiccups refractory to conventional agents, possibly by modulating aberrant central neural circuitry, and further prospective studies are warranted to establish standardized treatment protocols for this challenging and underrecognised condition.<\/jats:p>","DOI":"10.1002\/ccr3.73442","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:00:13Z","timestamp":1788328813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Persistent Post\u2010Traumatic Brain Injury Hiccups Unresponsive to Standard Agents: Resolution Associated With Levetiracetam Therapy"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3984-3038","authenticated-orcid":false,"given":"Rostom","family":"Karajeh","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Critical Care Palestinian Red Crescent Society  Hebron Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9665-0641","authenticated-orcid":false,"given":"Ranya Abu","family":"Khalaf","sequence":"additional","affiliation":[{"name":"Department of Clinical Medical Sciences, Faculty of Medicine and Health Sciences Palestine Polytechnic University  Hebron Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6833-5313","authenticated-orcid":false,"given":"Mostafa Ibraheem Abo","family":"Alrob","sequence":"additional","affiliation":[{"name":"Department of Clinical Medical Sciences, Faculty of Medicine and Health Sciences Palestine Polytechnic University  Hebron Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6465-7418","authenticated-orcid":false,"given":"Saif Khaled Abdalhadi","family":"Azzam","sequence":"additional","affiliation":[{"name":"Department of Clinical Medical Sciences, Faculty of Medicine and Health Sciences Palestine Polytechnic University  Hebron Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5225-145X","authenticated-orcid":false,"given":"Youssef Abdelqader","family":"Alsaeed","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Palestinian Red Crescent Society  Hebron Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(05)81620-8"},{"issue":"1","key":"e_1_2_13_3_1","article-title":"Interventions for Treating Persistent and Intractable Hiccups in Adults","volume":"2013","author":"Moretto E. 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