{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:55:14Z","timestamp":1791273314468,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This case highlights the importance of genetic evaluation during treatment in young patients with advanced ovarian cancer. Lynch syndrome caused by a germline MSH6 pathogenic variant was diagnosed during first\u2010line maintenance therapy, and pembrolizumab achieved a durable response in recurrent disease.<\/jats:p>","DOI":"10.1002\/ccr3.73444","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:15:45Z","timestamp":1788243345000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Benefit of Pembrolizumab in Lynch Syndrome\u2010Associated Advanced Ovarian Cancer With Germline\n                    <i>MSH6<\/i>\n                    Variant: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6027-7840","authenticated-orcid":false,"given":"Tomomi","family":"Yokozawa","sequence":"first","affiliation":[{"name":"Department of Gynecology Kanagawa Cancer Center  Yokohama Japan"},{"name":"Department of Obstetrics and Gynecology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2400-9061","authenticated-orcid":false,"given":"Sayako","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Gynecology Kanagawa Cancer Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2178-6562","authenticated-orcid":false,"given":"Yukio","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Gynecology Kanagawa Cancer Center  Yokohama Japan"},{"name":"Department of Obstetrics and Gynecology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7134-7437","authenticated-orcid":false,"given":"Aya","family":"Tokinaga\u2010Uchiyama","sequence":"additional","affiliation":[{"name":"Department of Gynecology Kanagawa Cancer Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2606-2950","authenticated-orcid":false,"given":"Katsuyuki","family":"Konnai","sequence":"additional","affiliation":[{"name":"Department of Gynecology Kanagawa Cancer Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0383-4911","authenticated-orcid":false,"given":"Hiroto","family":"Narimatsu","sequence":"additional","affiliation":[{"name":"Department of Genetic Medicine Kanagawa Cancer Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7384-3513","authenticated-orcid":false,"given":"Yukihiko","family":"Hiroshima","sequence":"additional","affiliation":[{"name":"Department of Cancer Genome Medicine Kanagawa Cancer Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2770-1731","authenticated-orcid":false,"given":"Haruya","family":"Saji","sequence":"additional","affiliation":[{"name":"Department of Gynecology Kanagawa Cancer Center  Yokohama Japan"},{"name":"Department of Obstetrics and Gynecology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) Genetic\/Familial High\u2010Risk Assessment: Colorectal, Endometrial, and Gastric","author":"Gupta S.","year":"2025"},{"key":"e_1_2_12_3_1","volume-title":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) Colon Cancer","author":"Benson A. B. I.","year":"2025"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2022-102123"},{"key":"e_1_2_12_5_1","volume-title":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) Ovarian Cancer Including Fallopian Tube Cancer and Primary Peritoneal Cancer","author":"Armstrong D. K.","year":"2025"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.07.011"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.9495"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314057"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.743"},{"issue":"7","key":"e_1_2_12_10_1","first-page":"1538","article-title":"The Clinical Features and Management of Lynch Syndrome\u2010Associated Ovarian Cancer","volume":"48","author":"Ran X.","year":"2022","journal-title":"Journal of Obstetrics and Gynaecology"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.12.005"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.5495"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.05.011"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2021.10.072"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.01.005"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309675"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2024.104119"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.18180"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.41648"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.6546"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-025-18400-8"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00958"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2024.11.011"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01207"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEG.S278054"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00197-8"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02105"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-025-03302-z"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.03023"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.16317"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2025.36.e59"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2021.09.006"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2020-002071"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-024-00357-4"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73444","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.73444","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73444","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:38:46Z","timestamp":1791272326000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.73444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/ccr3.73444"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.73444","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]},"assertion":[{"value":"2026-05-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e73444"}}