{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:54:44Z","timestamp":1791273284713,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The incidence of non\u2010small cell lung cancer (NSCLC) increases with age, with approximately half of the cases diagnosed in individuals aged 70 and older. In numerous clinical trials, immune checkpoint inhibitors (ICIs) have demonstrated significant efficacy in treating NSCLC without driver gene mutations. However, elderly lung cancer patients, particularly those aged 80 and above, are underrepresented in clinical trials, resulting in limited information on the efficacy and safety of ICIs in this population. This report details the clinical course of a 91\u2010year\u2010old patient with locally advanced NSCLC and an Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 2. The patient received nivolumab monotherapy at a dose of 200\u2009mg every 3\u2009weeks for the first four cycles, and then the dose was adjusted to 240\u2009mg every 3\u2009weeks from the fifth cycle, with a total of 32 treatment cycles administered. Treatment was well\u2010tolerated without significant immune\u2010related adverse events (irAEs). A durable partial response (PR) was achieved, with progression\u2010free survival (PFS) exceeding 31\u2009months. The patient maintained a favorable quality of life throughout the treatment period. This case suggests that initial low\u2010dose, extended\u2010interval individualized nivolumab therapy may serve as a treatment option for the oldest old patients with advanced NSCLC and poor PS.<\/jats:p>","DOI":"10.1002\/ccr3.73452","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:04:21Z","timestamp":1788242661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Initial Low\u2010Dose, Extended\u2010Interval Nivolumab Monotherapy in a 91\u2010Year\u2010Old Patient With Locally Advanced\n                    <scp>NSCLC<\/scp>\n                    and Poor Performance Status: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"given":"Dan","family":"Kou","sequence":"first","affiliation":[{"name":"Department of Geriatrics General Hospital of Western Theater Command  Chengdu Sichuan Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Geriatrics General Hospital of Western Theater Command  Chengdu Sichuan Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics General Hospital of Western Theater Command  Chengdu Sichuan Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingye","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Geriatrics General Hospital of Western Theater Command  Chengdu Sichuan Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongcheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Geriatrics General Hospital of Western Theater Command  Chengdu Sichuan Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Geriatrics General Hospital of Western Theater Command  Chengdu Sichuan Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2242-7074","authenticated-orcid":false,"given":"Xianhua","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics General Hospital of Western Theater Command  Chengdu Sichuan Province People's Republic of 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