{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:01:01Z","timestamp":1790226061780,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This report describes a 7\u2010year\u2010old boy with MOGAD presenting as severe ADEM with fever, encephalopathy, seizures, markedly elevated intracranial pressure, diffuse multifocal MRI abnormalities, and serum MOG\u2010IgG positivity. He required intravenous corticosteroids, plasma exchange, IVIG, and tocilizumab, followed by rehabilitation and maintenance IVIG. Persistent sequelae included dysarthria, memory and learning difficulties, and ADHD diagnosed after the acute illness. Approximately 3\u2009years later, he developed frequent hyperkinetic seizures with bifrontal\u2010predominant multifocal epileptiform abnormalities and subsequently achieved seizure freedom on combination therapy. Follow\u2010up contrast\u2010enhanced MRI after epilepsy onset demonstrated multifocal encephalomalacia\/gliosis and diffuse cerebral volume loss, without acute infarct, hemorrhage, mass effect, hydrocephalus, abnormal enhancement, or hippocampal abnormality. Prior inflammatory brain injury is therefore a plausible acquired substrate, but an independent genetic, traumatic, or other epilepsy predisposition cannot be excluded. The case emphasizes long\u2010term neurodevelopmental follow\u2010up after severe pediatric MOGAD\u2010ADEM and careful etiologic evaluation when remote epilepsy emerges.<\/jats:p>","DOI":"10.1002\/ccr3.73579","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:32:36Z","timestamp":1790224356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Severe Pediatric MOGAD\u2010Associated ADEM With Persistent Neurological Morbidity and Later\u2010Onset Epilepsy of Uncertain Etiology: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1042-4012","authenticated-orcid":false,"given":"Desiree\u2010Anne","family":"Ramsaran","sequence":"first","affiliation":[{"name":"Department of Pediatrics The Brooklyn Hospital Center  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3352-1446","authenticated-orcid":false,"given":"Garrett","family":"Gianneschi","sequence":"additional","affiliation":[{"name":"Department of Neurology Rutgers\u2010New Jersey Medical School  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Elgallab","sequence":"additional","affiliation":[{"name":"Department of Neurology Rutgers\u2010New Jersey Medical School  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.885218"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx276"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.13159"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458518823486"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.103216"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.593287"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2020.10.006"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000200174"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987\u2010022\u201000372\u20106"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17315"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20102525\u20103511"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1646"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000089"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73579","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.73579","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73579","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:32:51Z","timestamp":1790224371000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.73579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/ccr3.73579"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.73579","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]},"assertion":[{"value":"2026-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e73579"}}