{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:41:01Z","timestamp":1792734061151,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Low phospholipid\u2010associated cholelithiasis (LPAC) syndrome is a rare inherited disorder caused by\n                    <jats:italic>ABCB4<\/jats:italic>\n                    mutations with heterogeneous manifestations. We describe two LPAC cases in a mother\u2013son pair, detailing their clinical presentations, diagnostic evaluations, and management. A novel\n                    <jats:italic>ABCB4<\/jats:italic>\n                    frameshift variant (c.715_716insTT; p.Ser239PhefsTer9) was identified, expanding the genetic spectrum of LPAC syndrome.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.73591","type":"journal-article","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:17:27Z","timestamp":1791001047000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low Phospholipid\u2010Associated Cholelithiasis in a Mother\u2013Son Pair Associated With a Novel\n                    <scp>\n                      <i>ABCB4<\/i>\n                    <\/scp>\n                    Frameshift Variant"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2186-206X","authenticated-orcid":false,"given":"Hui\u2010Ming","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Hepatology Hunan Provincial People's Hospital and the First Affiliated Hospital of Hunan Normal University  Changsha Hunan China"},{"name":"Department of Gastroenterology Suining County People's Hospital  Shaoyang Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0268-8140","authenticated-orcid":false,"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hepatology Hunan Provincial People's Hospital and the First Affiliated Hospital of Hunan Normal University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7139-9328","authenticated-orcid":false,"given":"Zheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatology Hunan Provincial People's Hospital and the First Affiliated Hospital of Hunan Normal University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviscsurg.2019.02.006"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes13061047"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.23947"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2020.100201"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26424"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750\u20101172\u20102\u201029"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100030\u20101253223"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.04.036"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/hc9.0000000000000314"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.23984"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i19.5867"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065823"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2210\u20107401(12)70015\u20103"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/03602532.2021.2001493"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2010.07.007"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73591","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.73591","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:29:28Z","timestamp":1792733368000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.73591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/ccr3.73591"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.73591","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e73591"}}