{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:00:51Z","timestamp":1790312451907,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Distinguishing benign intranodal thyroid inclusions from metastatic papillary thyroid carcinoma is vital in synchronous malignancies to prevent overstaging. Integrating morphological analysis with BRAF VE1 immunohistochemistry ensures diagnostic precision to align management with the true pathological stage, avoiding unnecessary aggressive interventions like total thyroidectomy and radioactive iodine therapy.<\/jats:p>","DOI":"10.1002\/ccr3.73601","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:46:20Z","timestamp":1790311580000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Challenge of Contralateral Intranodal Thyroid Inclusions in a Patient With Synchronous Oropharyngeal and Papillary Thyroid Carcinoma: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7987-001X","authenticated-orcid":false,"given":"Bo\u2010Cheng","family":"Rau","sequence":"first","affiliation":[{"name":"Department of Education China Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010An","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology China Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7218-1864","authenticated-orcid":false,"given":"Chun\u2010Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery China Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"e_1_2_12_2_1","article-title":"Multiple Primary Malignancies in Head and Neck Cancer: A University Hospital Experience Over a Five\u2010Year Period","volume":"13","author":"Batista M. V.","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"4294","DOI":"10.1200\/JCO.2011.36.4596","article-title":"Human Papillomavirus and Rising Oropharyngeal Cancer Incidence in the United States","volume":"29","author":"Chaturvedi A. K.","year":"2011","journal-title":"Journal of Clinical Oncology"},{"key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1056\/NEJMp1604412","article-title":"Worldwide Thyroid\u2010Cancer Epidemic? The Increasing Impact of Overdiagnosis","volume":"375","author":"Vaccarella S.","year":"2016","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S2213-8587(20)30115-7","article-title":"Global Trends in Thyroid Cancer Incidence and the Impact of Overdiagnosis","volume":"8","author":"Li M.","year":"2020","journal-title":"Lancet Diabetes and Endocrinology"},{"key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1007\/s00405-015-3786-3","article-title":"Incidental Findings of Thyroid Tissue in Cervical Lymph Nodes: Old Controversy Not Yet Resolved?","volume":"273","author":"Triantafyllou A.","year":"2016","journal-title":"European Archives of Oto\u2010Rhino\u2010Laryngology"},{"key":"e_1_2_12_7_1","first-page":"113","volume-title":"AJCC Cancer Staging Manual","author":"Brain O'Sullivan W. M. L.","year":"2017"},{"key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New Response Evaluation Criteria in Solid Tumours: Revised RECIST Guideline (Version 1.1)","volume":"45","author":"Eisenhauer E. A.","year":"2009","journal-title":"European Journal of Cancer"},{"key":"e_1_2_12_9_1","first-page":"1039","article-title":"The 2023 Bethesda System for Reporting Thyroid Cytopathology","volume":"33","author":"Ali S. Z.","year":"2023","journal-title":"Thyroid"},{"key":"e_1_2_12_10_1","first-page":"873","volume-title":"AJCC Cancer Staging Manual","author":"Tuttle LFM R. M.","year":"2017"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1111\/his.15394","article-title":"Intranodal Thyroid Inclusions Revisited: A Morphological Analysis and Application of BRAF VE1 Immunohistochemistry","volume":"86","author":"Chuang Y. C.","year":"2025","journal-title":"Histopathology"},{"key":"e_1_2_12_12_1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s11864-022-00941-9","article-title":"Induction Chemotherapy in Low\u2010Risk HPV+ Oropharyngeal Cancer","volume":"23","author":"Dolezal J. M.","year":"2022","journal-title":"Current Treatment Options in Oncology"},{"key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.cell.2014.09.050","article-title":"Integrated Genomic Characterization of Papillary Thyroid Carcinoma","volume":"159","author":"Cancer Genome Atlas Research N","year":"2014","journal-title":"Cell"},{"key":"e_1_2_12_14_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/path.5005","article-title":"Genetic Landscape of Papillary Thyroid Carcinoma in the Chinese Population","volume":"244","author":"Liang J.","year":"2018","journal-title":"Journal of Pathology"},{"key":"e_1_2_12_15_1","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1210\/er.2007-0007","article-title":"BRAF Mutation in Papillary Thyroid Cancer: Pathogenic Role, Molecular Bases, and Clinical Implications","volume":"28","author":"Xing M.","year":"2007","journal-title":"Endocrine Reviews"},{"key":"e_1_2_12_16_1","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1177\/10507256251363120","article-title":"2025 American Thyroid Association Management Guidelines for Adult Patients With Differentiated Thyroid Cancer","volume":"35","author":"Ringel M. D.","year":"2025","journal-title":"Thyroid"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73601","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.73601","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73601","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:46:31Z","timestamp":1790311591000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.73601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/ccr3.73601"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.73601","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]},"assertion":[{"value":"2026-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e73601"}}