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This case highlights the importance of early clinical suspicion despite low LRINEC score. Prompt surgical intervention, appropriate antibiotics, and recognition of underlying conditions like polyarteritis nodosa are critical to reduce morbidity and mortality in rapidly progressive soft tissue infections.<\/jats:p>","DOI":"10.1002\/ccr3.73624","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:46:34Z","timestamp":1790405194000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rare Case of Necrotizing Fasciitis With Polyarteritis Nodosa in a Multi\u2010Comorbid Patient"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3664-151X","authenticated-orcid":false,"given":"Syed Muhammed Salman","family":"Hassan","sequence":"first","affiliation":[{"name":"Nishtar Medical University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1077-7993","authenticated-orcid":false,"given":"Sarim Hassan","family":"Shahab","sequence":"additional","affiliation":[{"name":"Nishtar Medical University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masroor","family":"Raza","sequence":"additional","affiliation":[{"name":"Ch Pervaiz Elahi Institute of Cardiology  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salman","family":"Saleem","sequence":"additional","affiliation":[{"name":"Multan Medical &amp; Dental College  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Fahad","family":"Hussain","sequence":"additional","affiliation":[{"name":"Multan Medical &amp; Dental College  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4915-9231","authenticated-orcid":false,"given":"Fazal","family":"Habib","sequence":"additional","affiliation":[{"name":"Sher\u2010e\u2010Bangla Medical College  Barisal Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1600673"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2017.05.011"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.97257"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102020\u2010041302"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(22)00583\u20107"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73624","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.73624","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:46:35Z","timestamp":1790405195000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.73624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":5,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/ccr3.73624"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.73624","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,25]]},"assertion":[{"value":"2026-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e73624"}}