{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:40:59Z","timestamp":1792734059942,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Dedifferentiated liposarcoma (DDLPS) is an aggressive malignant soft tissue tumor comprising approximately 15%\u201320% of all liposarcomas. When presenting in the extremities, its atypical clinical and radiological features may mimic vascular or infectious conditions, posing a serious diagnostic challenge that can delay curative intervention. A 60\u2010year\u2010old diabetic female presented with a 6\u2010month progressive left thigh mass accompanied by intermittent fever, significant weight loss, and refractory anemia. Doppler ultrasonography initially suggested a hemangioma; contrast\u2010enhanced CT was interpreted as an organized abscess. Ultrasound\u2010guided aspiration yielded 600\u2009mL of thick necrotic aspirate\u2014Gram stain demonstrated no organisms, culture was sterile, and aspirate cytology showed RBC 98,000 and WBC 25,000, confirming the absence of pyogenic infection. Concurrent core biopsy from the lesion wall established the diagnosis of DDLPS (FNCLCC Grade 2). PET\u2010CT confirmed locoregional disease without distant metastasis. Following surgical referral, the patient died suddenly overnight before planned excision. To our knowledge, this is the first reported case demonstrating the combined triad of Doppler\u2010based vascular mimicry, CT\u2010based abscess diagnosis, and large\u2010volume sterile necrotic aspirate in extremity DDLPS, culminating in sudden pre\u2010operative death. This case highlights that histopathological evaluation\u2014including concurrent biopsy of any aspirated deep soft tissue mass\u2014must not be deferred regardless of apparent microbiological findings.<\/jats:p>","DOI":"10.1002\/ccr3.73630","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:44:12Z","timestamp":1790405052000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Rare Case Report on Dedifferentiated Liposarcoma of the Thigh Mimicking an Abscess With Vascular Features: A Diagnostic Challenge With Fatal Outcome"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2515-3042","authenticated-orcid":false,"given":"Rashid Shahriar","family":"Sazal","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Bangladesh Medical University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9650-8561","authenticated-orcid":false,"given":"Md. Hashibul Hasan","family":"Shawon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Bangladesh Medical University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2299-0215","authenticated-orcid":false,"given":"Mahin","family":"Zubaer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Bangladesh Medical University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7771-1065","authenticated-orcid":false,"given":"Md. 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