{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:01:46Z","timestamp":1791464506362,"version":"4.3.4"},"reference-count":10,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Dengue fever is commonly associated with bleeding complications, particularly in patients with thrombocytopenia. However, thrombotic events, such as venous thromboembolism, are rare and under\u2010recognized manifestations, particularly during the recovery phase, posing diagnostic and therapeutic challenges. We report the case of a 25\u2010year\u2010old previously healthy male who presented with high\u2010grade fever, myalgia, and headache and was diagnosed with dengue fever based on positive NS1 antigen testing. Dengue infection was confirmed by a positive NS1 antigen test performed on Day 3 of illness, consistent with early acute dengue infection. The diagnosis was further supported by the patient's clinical presentation, including high\u2010grade fever, myalgia, and headache in the appropriate epidemiological context of a dengue\u2010endemic region. During the recovery phase of the illness, he developed painful swelling of the right lower limb and progressive dyspnea. Investigations revealed markedly elevated D\u2010dimer levels, right lower limb deep vein thrombosis on Doppler ultrasound, and bilateral pulmonary emboli with right ventricular strain on CT pulmonary angiography images. Although dengue\u2010associated thrombosis has been reported in the setting of thrombocytopenia, as described by Ghatak et\u00a0al., the present case demonstrates that thrombotic complications may also occur despite preserved platelet counts, highlighting the potential contribution of endothelial dysfunction and inflammatory activation. This case highlights the paradoxical coexistence of thrombosis and bleeding risk in dengue fever. To avoid potentially fatal thromboembolic complications in patients with dengue, early diagnosis, prompt anticoagulation, and a high index of suspicion are crucial.<\/jats:p>","DOI":"10.1002\/ccr3.73642","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:40:36Z","timestamp":1791463236000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Post\u2010Dengue Deep Vein Thrombosis Complicated by Pulmonary Embolism: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"given":"Sarah","family":"Nisar","sequence":"first","affiliation":[{"name":"Department of Medicine Khyber Teaching Hospital  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza","family":"Mushtaq","sequence":"additional","affiliation":[{"name":"Department of Medicine Sebring Advent Health  Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Haris","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Medicine Saidu Medical College  Swat Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8861-0367","authenticated-orcid":false,"given":"Fatima","family":"Sajjad","sequence":"additional","affiliation":[{"name":"Department of Medicine Khyber Medical College  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Afridi","sequence":"additional","affiliation":[{"name":"Department of Medicine Khyber Medical College  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor E","family":"Fatima","sequence":"additional","affiliation":[{"name":"Department of Medicine Khyber Medical College  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8208-0689","authenticated-orcid":false,"given":"Kamil Ahmad","family":"Kamil","sequence":"additional","affiliation":[{"name":"Nasrat Bashir Curative Hospital  Kandahar Afghanistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.31762\/AHJ2231.0103","article-title":"The Incidence of Venous Thromboembolism in Dengue Viral Infections: A Systematic Review","volume":"31","author":"Nugraha I. D.","year":"2022","journal-title":"ASEAN Heart Journal"},{"issue":"4","key":"e_1_2_14_3_1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00408-017-0021-6","article-title":"Dengue Hemorrhagic Fever: A State\u2010Of\u2010The\u2010Art Review Focused in Pulmonary Involvement","volume":"195","author":"Almeida R. R.","year":"2017","journal-title":"Lung"},{"issue":"1","key":"e_1_2_14_4_1","doi-asserted-by":"crossref","DOI":"10.1155\/crnm\/5368634","article-title":"Exploring Central Venous Thrombosis as a Rare Postinfectious Complication of Dengue: A Case Report","volume":"2025","author":"Mbah L. A.","year":"2025","journal-title":"Case Reports in Neurological Medicine"},{"issue":"9","key":"e_1_2_14_5_1","doi-asserted-by":"crossref","DOI":"10.1093\/ehjcr\/ytaf428","article-title":"Concomitant Acute Pulmonary Embolism in Recent Dengue Virus Infection in an Endemic Country: Case Series","volume":"9","author":"Putri A.","year":"2025","journal-title":"European Heart Journal \u2010 Case Reports"},{"issue":"3","key":"e_1_2_14_6_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4103\/jgid.jgid_217_24","article-title":"Spontaneous Venous Thrombosis in Patients With Dengue Fever: A Systematic Analysis of Published Case Reports","volume":"17","author":"Ghatak T.","year":"2025","journal-title":"Journal of Global Infectious Diseases"},{"issue":"7","key":"e_1_2_14_7_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005738","article-title":"Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to Hyperpermeability","volume":"12","author":"Puerta\u2010Guardo H.","year":"2016","journal-title":"PLoS Pathogens"},{"issue":"23","key":"e_1_2_14_8_1","doi-asserted-by":"crossref","first-page":"13759","DOI":"10.1128\/JVI.02166-14","article-title":"Molecular Mimicry Between Dengue Virus and Coagulation Factors Induces Antibodies to Inhibit Thrombin Activity and Enhance Fibrinolysis","volume":"88","author":"Chuang Y. C.","year":"2014","journal-title":"Journal of Virology"},{"key":"e_1_2_14_9_1","first-page":"563","volume-title":"Seminars in Immunopathology","author":"Srikiatkhachorn A.","year":"2017"},{"issue":"10","key":"e_1_2_14_10_1","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.4103\/jfmpc.jfmpc_396_24","article-title":"Correlation Between CRP and Ferritin in Dengue Patients: A Hospital\u2010Based Prospective Observational Study","volume":"13","author":"Nayak S.","year":"2024","journal-title":"Journal of Family Medicine and Primary Care"},{"issue":"3","key":"e_1_2_14_11_1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1086\/341410","article-title":"Coagulation Abnormalities in Dengue Hemorrhagic Fever: Serial Investigations in 167 Vietnamese Children With Dengue Shock Syndrome","volume":"35","author":"Wills B. A.","year":"2002","journal-title":"Clinical Infectious Diseases"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73642","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.73642","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73642","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:40:39Z","timestamp":1791463239000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.73642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/ccr3.73642"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.73642","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e73642"}}