{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:08:18Z","timestamp":1753862898521,"version":"3.41.2"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>In conclusion author highlights the tumor cell genetic testing or molecular pathological diagnosis plays a key role in the individualized treatment of PSC, which could benefit patients with advanced PSC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>An uncommon form of non\u2010small\u2010cell lung cancer (NSCLC) with a poor prognosis is pulmonary sarcomatoid carcinoma (PSC). Surgical resection is currently the preferred treatment, but guidelines for adjuvant chemotherapy have not yet been established, especially for the advanced stage. The development of molecular subgroups in the field of tumors may be advantageous to advanced PSC patients with the ongoing progress of genomics and immunology. A 54\u2010year\u2010old man presented to Xishan People's Hospital of Wuxi City with recurrent intermittent dry cough with fever for 1\u2009month. Further examinations suggested the diagnosis of PSC occupying almost the entire right interlobar fissure area combined with malignant pleural effusion (Stage IVa). Pathological examination confirmed the diagnosis of PSC with <jats:italic>ROS1<\/jats:italic> overexpressing via genetic testing. However, after three cycles of chemo\u2010, antiangiogenetic\u2010 and immunochemical therapy, the lesion was localized, and pleural effusion disappeared, the patient subsequently received an operation which was performed as R0 resection. Unfortunately, the patient became deteriorated quickly followed by extensive metastatic nodules in the thoracic cavity. Although the patient continued to receive chemo\u2010 and immunochemical\u2010therapy, it did not limit the progress of the tumor, leading to widespread metastasis, and eventually died of multiple organ failure. For PSC patients with Stage IVa, chemo\u2010, antiangiogenetic\u2010 and immunochemical\u2010therapy performs well in clinical efficacy, and comprehensive panel\u2010based genetic testing may offer PSC patients a somewhat better prognosis. However, blindly implementing surgical treatment may bring harm to the patient and affect long\u2010term survival. It's essential to know the surgical indications precisely by NSCLC guidelines.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.7365","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T06:21:34Z","timestamp":1684477294000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive treatment for <scp><i>ROS1<\/i><\/scp>\u2010overexpressed pulmonary sarcomatoid carcinoma: A case report"],"prefix":"10.1002","volume":"11","author":[{"given":"Wei","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Xishan People's Hospital of Wuxi City  Wuxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinlian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Xishan People's Hospital of Wuxi City  Wuxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qifeng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pathology Xishan People's Hospital of Wuxi City  Wuxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology the First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5963-5295","authenticated-orcid":false,"given":"Chaobo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Surgery Xishan People's Hospital of Wuxi City  Wuxi China"},{"name":"Department of Hepatic\u2010Biliary\u2010Pancreatic Surgery The Affiliated Drum Tower Hospital of Nanjing University Medical school  Nanjing China"},{"name":"Department of Immunology, Ophthalmology &amp; 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