{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:57:50Z","timestamp":1790747870535,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Mixed neuroendocrine\u2013non\u2010neuroendocrine neoplasms (MiNENs) of the gallbladder are exceedingly rare entities. We report a case of a 35\u2010year\u2010old female with a palpable right hypochondrial mass. Imaging demonstrated a large polypoid gallbladder lesion with periportal lymphadenopathy. The patient underwent open cholecystectomy with lymphadenectomy. Histopathology and immunohistochemistry revealed a MiNEN. At 12\u2010month follow\u2010up, she remained free of recurrence without any adjuvant chemotherapy.<\/jats:p>","DOI":"10.1002\/ccr3.73652","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:08:05Z","timestamp":1790744885000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mixed Neuroendocrine\u2014Non\u2010Neuroendocrine Neoplasm (\n                    <scp>MiNEN<\/scp>\n                    ) of the Gallbladder. A Case Report From a Low\u2010Resource Setting"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3839-4693","authenticated-orcid":false,"given":"Muhammad","family":"Farhan","sequence":"first","affiliation":[{"name":"Department of General Surgery Shaheed Saif Ur Rehman Government Teaching Hospital  Gilgit Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Imran","sequence":"additional","affiliation":[{"name":"Department of General Surgery Shaheed Saif Ur Rehman Government Teaching Hospital  Gilgit Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4582-0024","authenticated-orcid":false,"given":"Beenish","family":"Sabir","sequence":"additional","affiliation":[{"name":"Rawalpindi Medical University  Rawalpindi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of General Surgery Shaheed Saif Ur Rehman Government Teaching Hospital  Gilgit Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farheen","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of General Surgery Shaheed Saif Ur Rehman Government Teaching Hospital  Gilgit Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahid","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of General Surgery Shaheed Saif Ur Rehman Government Teaching Hospital  Gilgit Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohaib","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of General Surgery Shaheed Saif Ur Rehman Government Teaching Hospital  Gilgit Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Asim","sequence":"additional","affiliation":[{"name":"Department of General Surgery Shaheed Saif Ur Rehman Government Teaching Hospital  Gilgit Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9997-1143","authenticated-orcid":false,"given":"Iqra","family":"Mehmood","sequence":"additional","affiliation":[{"name":"Department of Histopathology Shifa International Hospital  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9830-5649","authenticated-orcid":false,"given":"Rahmat Gul","family":"Omarzai","sequence":"additional","affiliation":[{"name":"Department of Medicine Nangarhar University  Daronta, Nangarhar Afghanistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"issue":"1","key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1159\/000513031","article-title":"Recurrent Mixed Neuroendocrine\u2010Non\u2010Neuroendocrine Neoplasm in the Gallbladder: A Case Report","volume":"14","author":"Al\u2010Fayea T.","year":"2021","journal-title":"Case Reports in Oncology"},{"issue":"4","key":"e_1_2_13_3_1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/pin.13317","article-title":"Low\u2010Grade Mixed Neuroendocrine\u2010Non\u2010Neuroendocrine Neoplasm of the Extrahepatic Bile Duct: A Rare Tumour With 11\u2009Years' Follow\u2010Up Before Surgery","volume":"73","author":"Kubota K.","year":"2023","journal-title":"Pathology International"},{"issue":"1","key":"e_1_2_13_4_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s40792-022-01386-w","article-title":"Surgical Resection of Mixed Neuroendocrine\u2010Non\u2010Neuroendocrine Neoplasm in the Biliary System: A Report of Two Cases","volume":"8","author":"Tamaki A.","year":"2022","journal-title":"Surgical Case Reports"},{"issue":"19","key":"e_1_2_13_5_1","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.3748\/wjg.v28.i19.2076","article-title":"Mixed Neuroendocrine\u2010Non\u2010Neuroendocrine Neoplasms of the Digestive System: A Mini\u2010Review","volume":"28","author":"Toor D.","year":"2022","journal-title":"World Journal of Gastroenterology"},{"issue":"1","key":"e_1_2_13_6_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13000-022-01231-6","article-title":"Mixed Neuroendocrine\u2010Non\u2010Neuroendocrine Neoplasm of the Gallbladder: Case Report and Literature Review","volume":"17","author":"Ren X.","year":"2022","journal-title":"Diagnostic Pathology"},{"key":"e_1_2_13_7_1","doi-asserted-by":"crossref","DOI":"10.12659\/AJCR.929511","article-title":"Rare Mixed Adenoneuroendocrine Carcinoma of the Gallbladder: Case Report and Review of Literature","volume":"22","author":"Costa A. C.","year":"2021","journal-title":"American Journal of Case Reports"},{"issue":"1","key":"e_1_2_13_8_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12957-019-1598-4","article-title":"Mixed Neuroendocrine\u2010Non\u2010Neuroendocrine Carcinoma of Gallbladder: Case Report","volume":"17","author":"Skalick\u00fd A.","year":"2019","journal-title":"World Journal of Surgical Oncology"},{"issue":"1","key":"e_1_2_13_9_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s12328-021-01547-8","article-title":"Focal Neuroendocrine Carcinoma Mixed With Adenocarcinoma of the Gallbladder With Aggressive Lymph Node Metastasis in a Patient Who Did Not Meet the Mixed Neuroendocrine\u2013Non\u2010Neuroendocrine Neoplasm Criteria","volume":"15","author":"Kadota Y.","year":"2022","journal-title":"Clinical Journal of Gastroenterology"},{"issue":"2","key":"e_1_2_13_10_1","first-page":"48","article-title":"Targeted Sequencing of Mixed Neuroendocrine\u2010 Non\u2010Neuroendocrine Neoplasm of the Gallbladder Suggests a Monoclonal Origin: A Case Report","volume":"4","author":"Sta. Ines F. M.","year":"2019","journal-title":"Pakistan Journal of Pharmacology"},{"issue":"6","key":"e_1_2_13_11_1","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1093\/ajcp\/aqaf013","article-title":"Histopathologic and Genetic Distinction of Well\u2010Differentiated Grade 3 Neuroendocrine Tumor Versus Poorly\u2010Differentiated Neuroendocrine Carcinoma in High\u2010Grade Neuroendocrine Neoplasms","volume":"163","author":"Sun B. L.","year":"2025","journal-title":"American Journal of Clinical Pathology"},{"issue":"3","key":"e_1_2_13_12_1","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s12022-022-09722-4","article-title":"Molecular Subtypes of Extra\u2010Pulmonary Neuroendocrine Carcinomas Identified by the Expression of Neuroendocrine Lineage\u2010Specific Transcription Factors","volume":"33","author":"Metovic J.","year":"2022","journal-title":"Endocrine Pathology"},{"issue":"1","key":"e_1_2_13_13_1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s40792-021-01152-4","article-title":"Mixed Neuroendocrine\u2010Non\u2010Neuroendocrine Neoplasms of the Gallbladder: A Case Report","volume":"7","author":"Ishikawa T.","year":"2021","journal-title":"Surgical Case Reports"},{"issue":"3","key":"e_1_2_13_14_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jscr\/rjad132","article-title":"Mixed Neuroendocrine\u2010Non\u2010Neuroendocrine Carcinoma (MiNEN) in Gallbladder With Liver Metastasis of Neuroendocrine Carcinoma Component: A Case Report","volume":"2023","author":"In Park S.","year":"2023","journal-title":"Journal of Surgical Case Reports"},{"issue":"12","key":"e_1_2_13_15_1","doi-asserted-by":"crossref","DOI":"10.14309\/crj.0000000000001566","article-title":"Endoscopic Ultrasound\u2010Guided Diagnosis of Gallbladder Mixed Neuroendocrine Non\u2010Neuroendocrine Tumor With an Anomalous Pancreaticobiliary Junction","volume":"11","author":"Tsuchiyose E.","year":"2024","journal-title":"ACG Case Reports Journal"},{"issue":"1","key":"e_1_2_13_16_1","doi-asserted-by":"crossref","first-page":"n\/a","DOI":"10.70352\/scrj.cr.24-0097","article-title":"Gallbladder Mixed Neuroendocrine\u2013Non\u2010Neuroendocrine Neoplasm Consisting of Adenocarcinoma and Neuroendocrine Tumor G2 Diagnosed After Surgery for Acute Cholecystitis: A Case Report and Exome Analysis","volume":"11","author":"Seki T.","year":"2025","journal-title":"Surgical Case Reports"},{"key":"e_1_2_13_17_1","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2025.1606850","article-title":"Case Report: Diagnosing and Treating Gallbladder Neuroendocrine Neoplasms Through Comparative Analysis: A Case Series and Literature Review","volume":"15","author":"Zhang J.","year":"2025","journal-title":"Frontiers in Oncology"},{"issue":"1","key":"e_1_2_13_18_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s12957-024-03436-z","article-title":"Clinical Diagnosis and Treatment of 37 Cases of Gallbladder Neuroendocrine Carcinoma","volume":"22","author":"Liu F.","year":"2024","journal-title":"World Journal of Surgical Oncology"},{"key":"e_1_2_13_19_1","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.770156","article-title":"Case Report: Response With Immunotherapy in a Patient With Mixed Neuroendocrine Non\u2010Neuroendocrine Neoplasms of the Gallbladder","volume":"11","author":"Liu C.","year":"2021","journal-title":"Frontiers in Oncology"},{"issue":"17","key":"e_1_2_13_20_1","doi-asserted-by":"crossref","first-page":"5021","DOI":"10.3390\/jcm11175021","article-title":"Pancreatic Adeno\u2010MiNEN, a Rare Newly Defined Entity With Challenging Diagnosis and Treatment: A Case Report With Systematic Literature Review and Pooled Analysis","volume":"11","author":"Angelico R.","year":"2022","journal-title":"Journal of Clinical Medicine"},{"issue":"16","key":"e_1_2_13_21_1","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.2169\/internalmedicine.4996-24","article-title":"Multimodal Treatment Approach for Mixed Neuroendocrine\u2010Non\u2010Neuroendocrine Neoplasms of the Gallbladder: A Patient With a Favorable Survival Outcome","volume":"64","author":"Oe S.","year":"2025","journal-title":"Internal Medicine"},{"issue":"1","key":"e_1_2_13_22_1","first-page":"P146","article-title":"Complete Response to Lutetium \u2212177 DOTATATE Therapy in a Case of Gall Bladder Mixed Neuroendocrine Neoplasm(GB\u2010MiNEN) With Extensive Liver and Skeletal Marrow Metastases","volume":"64","author":"Kamaleshwaran K. 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