{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:54:12Z","timestamp":1791179652825,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Some of the rarest diseases with cell accumulation in different organs are histiocytoses. Since these diagnoses are uncommon, other differential diagnoses must be excluded. We report a case of a 42\u2010year\u2010old man with episodes of knee pain and fever. Multiple sclerotic bone lesions were discovered by\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010fluorodeoxyglucose positron emission tomography\u2010computed tomography (FDG PET\/CT). A bone biopsy was taken, and it showed a mixed infiltrate consisting of mature lymphocytes, plasma cells, and many histiocytes (CD68\n                    <jats:sup>\n                      <jats:italic>+<\/jats:italic>\n                    <\/jats:sup>\n                    \/CD163\n                    <jats:sup>\n                      <jats:italic>+<\/jats:italic>\n                    <\/jats:sup>\n                    \/S\u2010100\n                    <jats:sup>\n                      <jats:italic>\u2212\/+<\/jats:italic>\n                    <\/jats:sup>\n                    \/CD1a\n                    <jats:sup>\n                      <jats:italic>\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    \/langerin\n                    <jats:sup>\n                      <jats:italic>\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    ), including some foamy macrophages and cells with emperipolesis. Histology showed characteristics for both Erdheim\u2013Chester disease (ECD) and Rosai\u2013Dorfman disease (RDD). Molecular analysis showed MAP2K1 mutation that can be seen with both diseases. Considering the clinical manifestations that resembled ECD and histologic RDD\u2010like features, a diagnosis of overlap between ECD and RDD with isolated multifocal bone involvement was made. Treatment with pegylated interferon alfa (Peg\u2010IFN\u2010\u03b1) was started, and after three months clear clinical improvement was reported by the patient, although PET\/CT demonstrated metabolically stable disease.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.73679","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:29:11Z","timestamp":1791178151000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Overlap of Erdheim\u2013Chester Disease and Rosai\u2013Dorfman Disease With Isolated Bone Lesions Presenting a Diagnostic Challenge: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6941-9102","authenticated-orcid":false,"given":"Maris","family":"Tulk","sequence":"first","affiliation":[{"name":"Department of Immunology Institute of Biomedicine and Translational Medicine, University of Tartu  Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reet","family":"Kuuse","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Tartu University Hospital  Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maksim","family":"Zagura","sequence":"additional","affiliation":[{"name":"Radiology Clinic Tartu University Hospital  Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazem M. M.","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Tartu University Hospital  Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liis","family":"Vahesaar","sequence":"additional","affiliation":[{"name":"Department of Pathology Tartu University Hospital  Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201001\u2010690636"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.24031"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000545775"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.216937"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201003\u2010839753"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath\u20102020\u2010206733"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2016001784"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019003507"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201005\u2010430140"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtauto.2021.100095"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41120"},{"issue":"1","key":"e_1_2_13_13_1","first-page":"19","article-title":"Sinus Histiocytosis With Massive Lymphadenopathy (Rosai\u2010Dorfman Disease): Review of the Entity","volume":"7","author":"Foucar E.","year":"1990","journal-title":"Seminars in Diagnostic Pathology"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1720131"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023\u2010018\u20100988\u2010y"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73679","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.73679","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73679","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:29:12Z","timestamp":1791178152000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.73679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/ccr3.73679"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.73679","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e73679"}}