{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:40:52Z","timestamp":1792734052437,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Sertoli\u2013Leydig cell tumors (SLCTs) are rare ovarian sex cord\u2010stromal tumors, particularly uncommon in the pediatric population. They are typically androgen\u2010secreting, while estrogen\u2010secreting forms are rare and may lead to diagnostic confusion with granulosa cell tumors. We report the case of a 7\u2010year\u2010old girl presenting with progressive abdominal distension and isosexual precocious puberty. Imaging revealed a large abdominopelvic mass of uncertain origin. Histopathological examination of a biopsy suggested a sex cord\u2010stromal tumor. The patient received neoadjuvant chemotherapy with the VIP regimen, resulting in significant tumor reduction, followed by fertility\u2010sparing surgery. Final histopathological and immunohistochemical analysis confirmed a SLCT. The tumor was classified as FIGO stage IC2 due to preoperative capsular breach. Postoperatively, an additional cycle of chemotherapy was administered. Hormonal markers, including estradiol and inhibin B, normalized after treatment. During follow\u2010up, a transient rise in these markers was observed in the absence of radiological abnormalities, followed by spontaneous normalization. The patient remains in complete remission after 27\u2009months of follow\u2010up. This case highlights an atypical estrogen\u2010secreting pediatric SLCT and underscores the importance of histopathological confirmation in unusual clinical presentations. It also illustrates the potential role of neoadjuvant chemotherapy in large tumors and supports the use of inhibin B as a biomarker for disease monitoring, although its interpretation should be cautious and integrated with clinical and imaging findings. Long\u2010term follow\u2010up is essential due to the risk of recurrence.<\/jats:p>","DOI":"10.1002\/ccr3.73700","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:46:37Z","timestamp":1792068397000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multidisciplinary Management of a Giant Ovarian Sertoli\u2013Leydig Cell Tumor Presenting With Isosexual Precocious Puberty: A Pediatric Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3696-4130","authenticated-orcid":false,"given":"Sanaa","family":"Bouramdane","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Hassan II University Hospital, Faculty of Medicine and Pharmacy Sidi Mohamed Ben Abdellah University  Fez Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4201-2005","authenticated-orcid":false,"given":"Kenza","family":"Elmkaddem","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Hassan II University Hospital, Faculty of Medicine and Pharmacy Sidi Mohamed Ben Abdellah University  Fez Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawal","family":"Hammas","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hassan II University Hospital, Faculty of Medicine and Pharmacy Sidi Mohamed Ben Abdellah University  Fez Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryem","family":"Boubbou","sequence":"additional","affiliation":[{"name":"Department of Mother and Child Radiology, Hassan II University Hospital, Faculty of Medicine and Pharmacy Sidi Mohamed Ben Abdellah University  Fez 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