{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:40:50Z","timestamp":1792734050486,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We report a 7\u2010year\u2010old male with microcephaly, spasticity, strabismus, dysmorphism, autistic behaviors, and moderate ID due to a novel\n                    <jats:italic>de novo<\/jats:italic>\n                    likely pathogenic\n                    <jats:italic>CTNNB1<\/jats:italic>\n                    variant (c.2215A&gt;C, p.Met739Leu). This case underscores Whole Exome Sequencing's diagnostic utility for early detection of rare monogenic neurodevelopmental disorders.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.73743","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:56:03Z","timestamp":1792155363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel\n                    <i>De Novo<\/i>\n                    Heterozygous Missense Variant in\n                    <scp>\n                      <i>CTNNB1<\/i>\n                    <\/scp>\n                    (c.\n                    <scp>2215A<\/scp>\n                    &gt;C, p.\n                    <scp>Met739Leu<\/scp>\n                    ) Underlying Neurodevelopmental Disorder With Spastic Diplegia and Visual Defects (\n                    <scp>NEDSDV<\/scp>\n                    ): A Case 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