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Skeletal metastasis, especially mixed lytic\u2010sclerotic lesions, is rare and typically occurs late. This report highlights an unusual presentation where widespread bony metastases were the initial manifestation, leading to the diagnosis of gallbladder carcinoma.<\/jats:p>","DOI":"10.1002\/ccr3.73745","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:43:26Z","timestamp":1792068206000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Disseminated Mixed Lytic\u2010Sclerotic Skeletal Metastases as Initial Presentation of Gallbladder Carcinoma: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"given":"Shivali","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Radiology Tribhuvan University Teaching Hospital  Kathmandu Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binaya","family":"Adhikari","sequence":"additional","affiliation":[{"name":"Department of Radiology Tribhuvan University Teaching Hospital  Kathmandu Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3947-6408","authenticated-orcid":false,"given":"Abhikanta","family":"Khatiwada","sequence":"additional","affiliation":[{"name":"Department of Radiology Tribhuvan University Teaching Hospital  Kathmandu Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12029\u2010014\u20109666\u2010z"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/cco.2019.08.03"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_8_6_1","volume-title":"StatPearls [Internet]","author":"Menon G.","year":"2025"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102023\u2010257753"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i22.3978"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.12659\/PJR.895190"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.5430\/jbgc.v3n2p24"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2014\/7057.4486"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15205055"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1102\/1470\u20107330.2010.0014"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v7.i8.202"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.772530"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20200726"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800680307"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v3.i3.231"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.18535\/jmscr\/v7i8.02"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.10.506"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73745","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.73745","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.73745","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:27:34Z","timestamp":1792733254000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.73745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/ccr3.73745"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.73745","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.174815120.09338372\/v1","asserted-by":"object"}]},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2025-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e73745"}}