{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:08:21Z","timestamp":1753862901634,"version":"3.41.2"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T00:00:00Z","timestamp":1685664000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Leukopenia, including agranulocytosis, is a severe complication of treatment with all \u03b2\u2010lactam antibiotics. Its incidence increases with age. <jats:italic>Cardiobacterium hominis<\/jats:italic> endocarditis after implantation of an aortic valve bio\u2010prosthesis in a 77\u2010year\u2010old woman was treated with ceftriaxone 2\u2009g\/day plus gentamicin 160\u2009mg\/day intravenously. On Day 25 of treatment, blood leukocytes had decreased to 1800\/\u03bcl (neutrophils 370\/\u03bcl). Antibiotic therapy was switched to penicillin G 20 million international units (IU)\/day. Thereafter, blood leukocytes including neutrophils normalized suggesting that penicillin G was less bone marrow\u2010toxic than ceftriaxone. High\u2010dose ciprofloxacin, the alternative to penicillin G, was avoided because of the risk of cognitive and behavioral side effects. The present case suggests that with close laboratory monitoring a \u03b2\u2010lactam with differing side chains should not be considered contraindicated after \u03b2\u2010lactam antibiotic\u2010induced neutropenia.<\/jats:p>","DOI":"10.1002\/ccr3.7462","type":"journal-article","created":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T04:45:15Z","timestamp":1685767515000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ceftriaxone\u2010induced neutropenia successfully overcome by a switch to penicillin G in <i>Cardiobacterium hominis<\/i> endocarditis"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8316-995X","authenticated-orcid":false,"given":"Roland","family":"Nau","sequence":"first","affiliation":[{"name":"Department of Neuropathology University Medical Center G\u00f6ttingen, Georg\u2010August\u2010University G\u00f6ttingen  G\u00f6ttingen Germany"},{"name":"Department of 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