{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:07:52Z","timestamp":1753862872385,"version":"3.41.2"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>When faced with a slowly enlarging firm mass in the parotid gland accompanied by a histological picture of unusual sclerosis with abundant Langerhans cells and eosinophilic infiltrates, sclerosing mucoepidermoid carcinoma with eosinophilia should be considered as one of the differential diagnoses. Further studies are warranted for accurate diagnosis and appropriate treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Sclerosing mucoepidermoid carcinoma of the salivary gland with eosinophilia is a rare tumor mostly negative for the MAML2 rearrangement commonly seen in salivary mucoepidermoid carcinoma. It was not listed as an entity in the 2022 WHO Classification of Head and Neck Tumors. We presented one case initially diagnosed as Langerhans cell histiocytosis and recurred as a frankly invasive carcinoma. Molecular studies showed CSF1 gene derangement and provided new understanding concerning the Langerhans cell and eosinophilic reaction. Further molecular studies on this entity would throw light on its oncogenesis and refine its nomenclature.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.7488","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T05:41:50Z","timestamp":1686202910000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Detection of <scp>CSF1<\/scp> gene derangement in \u2018sclerosing mucoepidermoid carcinoma with eosinophilia\u2019 of the parotid gland masquerading as Langerhans cell histiocytosis"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4820-8922","authenticated-orcid":false,"given":"Florence Man Fung","family":"Cheung","sequence":"first","affiliation":[{"name":"Clinical Laboratory Gleneagles Hospital Hong Kong  Hong Kong Hong Kong"},{"name":"Department of Pathology University of Hong Kong  Hong Kong Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chit","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Anatomical and Cellular Pathology Chinese University of Hong Kong  Hong Kong Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimmy Yu Wai","family":"Chan","sequence":"additional","affiliation":[{"name":"Chief of Division of Head and Neck Surgery and Division of Plastic and Reconstructive Surgery, School of Medicine University of Hong Kong  Hong Kong Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1078\/0344-0338-00259"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12035"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-015-0525-8"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-021-00285-7"},{"volume-title":"WHO classification of tumours editorial board. 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