{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:07:48Z","timestamp":1753862868930,"version":"3.41.2"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>When managing patients with differentiated thyroid cancers (DTC) and lytic bone lesions, physicians should consider etiologies other than DTC bony metastases when there is no biochemical and functional radiographic evidence of extensive DTC burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Systemic mastocytosis (SM) is a clonal expansion of mast cells associated with an increased risk of solid malignancies. There is no known association between systemic mastocytosis and thyroid cancer. We report a young woman who presented with cervical lymphadenopathy, palpable thyroid nodule, and lytic bone lesions who was diagnosed with papillary thyroid cancer (PTC). The patient's post\u2010surgical thyroglobulin was lower than expected for metastatic thyroid cancer, and the lytic bone lesions did not demonstrate uptake of I<jats:sup>123<\/jats:sup>. Upon further evaluation, the patient was found to have SM. We report a case of co\u2010occurrence of PTC and SM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.7507","type":"journal-article","created":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T04:20:03Z","timestamp":1688185203000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Simultaneous diagnosis of papillary thyroid cancer and systemic mastocytosis"],"prefix":"10.1002","volume":"11","author":[{"given":"Kevin F.","family":"Brown","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Medicine Walter Reed National Military Medical Center  Bethesda Maryland United States"},{"name":"Division of Endocrinology, Department of Medicine Uniformed Service University of the Health Sciences  Bethesda Maryland United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary W.","family":"Bloomer","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine Walter Reed National Military Medical Center  Bethesda Maryland United States"},{"name":"Division of Endocrinology, Department of Medicine Uniformed Service University of the Health Sciences  Bethesda Maryland United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5614-6402","authenticated-orcid":false,"given":"Mohamed K. M.","family":"Shakir","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine Walter Reed National Military Medical Center  Bethesda Maryland United States"},{"name":"Division of Endocrinology, Department of Medicine Uniformed Service University of the Health Sciences  Bethesda Maryland United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Cognetti","sequence":"additional","affiliation":[{"name":"Department of Pathology Walter Reed National Military Medical Center  Bethesda Maryland United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannie M.","family":"Muir","sequence":"additional","affiliation":[{"name":"Department of Pathology Walter Reed National Military Medical Center  Bethesda Maryland United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7437-5604","authenticated-orcid":false,"given":"Thanh D.","family":"Hoang","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine Walter Reed National Military Medical Center  Bethesda Maryland United States"},{"name":"Division of Endocrinology, Department of Medicine Uniformed Service University of the Health Sciences  Bethesda Maryland United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30201"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/705169"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbo.2020.100282"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25371"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24490"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2019.32.169.16640"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1169"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-09-731893"},{"issue":"2","key":"e_1_2_11_10_1","first-page":"22","article-title":"Skin and bones: systemic mastocytosis and bone","volume":"2023","author":"Wang M","year":"2023","journal-title":"Endocrinol Diabetes Metab Case Rep"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02780.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/869242"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.12730.1"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.7507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T08:37:43Z","timestamp":1692261463000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.7507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,30]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1002\/ccr3.7507"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.7507","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2023,6,30]]},"assertion":[{"value":"2022-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e7507"}}