{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:07:55Z","timestamp":1753862875580,"version":"3.41.2"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T00:00:00Z","timestamp":1687132800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>Bilateral thalamic infarction in paramedian artery territory may present with severe acute illness, confusion, coma and memory impairment. However, subtle clinical presentation as in our case should alert the clinician to consider such a diagnosis as it can be associated with good prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Bilateral thalamic infarct is a rare form of stroke. Mostly thalamic infarcts are unilateral. In most cases, bilateral thalamic infarction leads to cognitive dysfunction, opthalmoparesis, conscious impairment, behavioral disturbance, and corticospinal dysfunction. Here, we describe the case of a 75\u2010year\u2010old male patient who presented to the emergency department of our hospital with agitation and somnolence for one day. He had poorly controlled hypertension. There was no previous history of stroke, diabetes mellitus, hyperlipidemia, known cardiac disease, or smoking history. There was no seizure, recent headache, or visual disturbance. The patient was somnolent and not oriented to time, person, or place. Neurological examination did not show any focal weakness or vertical eye movement restrictions. Other systemic examinations, including those of the respiratory and cardiovascular systems, were unremarkable. Extensive laboratory investigations excluded potential metabolic, infectious, endocrine, or toxic etiologies. The patient did not have any recent history of drug misuse, including benzodiazepines. Brain MRI with diffusion\u2010weighted imaging showed an acute bilateral thalamic infarct. Cerebral angiography was unremarkable. The patient was treated with low molecular weight heparin 60\u2009mg subcutaneously, aspirin 300\u2009mg daily, and haloperidol 5\u2009mg twice daily for agitation. After two weeks of intrahospital treatment, his condition improved (consciousness and orientation massively improved).<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.7590","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T04:38:23Z","timestamp":1687235903000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Agitation and somnolence by bilateral paramedian thalamic infarct"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7236-1524","authenticated-orcid":false,"given":"Mohamed","family":"Sheikh\u00a0Hassan","sequence":"first","affiliation":[{"name":"Department of Neurology Mogadishu Somalia Turkish Training and Research Hospital  Mogadishu Somalia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6039-5054","authenticated-orcid":false,"given":"Nor","family":"Osman\u00a0Sidow","sequence":"additional","affiliation":[{"name":"Department of Neurology Mogadishu Somalia Turkish Training and Research Hospital  Mogadishu Somalia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdiladhif","family":"Mohamed\u00a0Ali","sequence":"additional","affiliation":[{"name":"Department of Neurology Mogadishu Somalia Turkish Training and Research Hospital  Mogadishu Somalia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Farah","family":"Osman","sequence":"additional","affiliation":[{"name":"Department of Neurology Mogadishu Somalia Turkish Training and Research Hospital  Mogadishu Somalia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdiwahid","family":"Ahmed\u00a0Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Neurology Mogadishu Somalia Turkish Training and Research Hospital  Mogadishu Somalia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Said","family":"Abdirahman\u00a0Ahmed","sequence":"additional","affiliation":[{"name":"Department of Cardiology Mogadishu Somalia Turkish Training and Research Hospital  Mogadishu Somalia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.03.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/wcs.1256"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000458705"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S119395"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000147039.49252.2f"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000087786.38997.9E"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/NRL.0000000000000047"},{"issue":"6","key":"e_1_2_10_9_1","article-title":"Bilateral thalamic infarction. Western","volume":"13","author":"Halac G","year":"2012","journal-title":"J Emerg Med"},{"issue":"10","key":"e_1_2_10_10_1","first-page":"2005","article-title":"Imaging of acute bilateral paramedian thalamic and mesencephalic infarcts","volume":"24","author":"Matheus MG","year":"2003","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.162045"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2044"},{"issue":"11","key":"e_1_2_10_13_1","article-title":"Bilateral thalamic stroke arising from an occlusion of the artery of Percheron: barriers to diagnosis, management, and recovery","volume":"13","author":"Satei AM","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2022.103674"},{"issue":"5","key":"e_1_2_10_15_1","article-title":"Bilateral thalamic ischemic stroke secondary to occlusion of the artery of Percheron","volume":"10","author":"Garcia\u2010Grimshaw MA","year":"2018","journal-title":"Cureus"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2022.104172"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/JMDH.S392922"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.7590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T16:04:59Z","timestamp":1692547499000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.7590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/ccr3.7590"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.7590","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"2023-04-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e7590"}}