{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T11:37:15Z","timestamp":1768304235024,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T00:00:00Z","timestamp":1401235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Key Clinical Message<\/jats:title><jats:p>The survival of multiple myeloma patients has improved very significantly over the last decade. Still median overall survival is inferior to 5\u00a0years. A small proportion of patients survive longer than 10\u00a0years. In this paper we discuss four cases illustrating the nonhomogeneous clinical presentation and evolution of this subset of patients. Surprisingly, these long survivors do not always have deep responses and some require frequent treatments, which include autologous stem cell transplantation and novel drugs. The authors discuss several aspects of these clinical histories, including treatment options, raising hypothesis on their relation with long survivorship which may be important to have in consideration when studying this subject.<\/jats:p>","DOI":"10.1002\/ccr3.76","type":"journal-article","created":{"date-parts":[[2014,5,29]],"date-time":"2014-05-29T02:52:20Z","timestamp":1401331940000},"page":"173-179","source":"Crossref","is-referenced-by-count":15,"title":["Long\u2010term survival in multiple myeloma"],"prefix":"10.1002","volume":"2","author":[{"given":"Cristina","family":"Jo\u00e3o","sequence":"first","affiliation":[{"name":"Department of Hematology IPOFG Lisboa Portugal"},{"name":"Clinical Research Unit IPOFG Lisboa Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Hematology IPOFG Lisboa Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u00eas","family":"Coelho","sequence":"additional","affiliation":[{"name":"Department of Hematology IPOFG Lisboa Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jo\u00e3o","family":"Vergueiro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine HFF Amadora Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mafalda","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Clinical Research Unit IPOFG Lisboa Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Gomes","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Hematology IPOFG Lisboa Portugal"},{"name":"Clinical Research Unit IPOFG Lisboa Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3322\/caac.20138","article-title":"Cancer statistics, 2012","volume":"62","author":"Siegel R.","year":"2013","journal-title":"CA Cancer J. Clin."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi098"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604607"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-116129"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70284-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.6820"},{"key":"e_1_2_8_8_1","first-page":"3972","article-title":"Continued improvement in survival in multiple myeloma and the impact of novel agents","volume":"120","author":"Kumar S. K.","year":"2012","journal-title":"ASH Annu. Meet. Abs."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.1916"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2013.01.019"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-08-040410"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.023"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-10-300970"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3257"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61188"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-358812"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.242"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2013.03.013"},{"key":"e_1_2_8_19_1","first-page":"4507","article-title":"Increased incidence of a second lymphoproliferative malignancy in patients with multiple myeloma \u2013 a SEER based study","volume":"32","author":"Chakraborty S.","year":"2012","journal-title":"Anticancer Res."},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1994.tb06745.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01462.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-008-0169-8"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2013.34"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404284"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.12.3832"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-405977"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2013.07.002"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-2159"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.5726"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-297853"},{"key":"e_1_2_8_31_1","doi-asserted-by":"crossref","unstructured":"Mikhael J. R. D.Dingli V.Roy C. B.Reeder F. K.Buadi S. R.Hayman et\u00a0al.2013. Pp.360\u2013376inManagement of newly diagnosed symptomatic multiple myeloma: updated mayo stratification of myeloma and risk\u2010adapted therapy (MSMART) consensus guidelines. Mayo Clin. Proc.88:360\u2013376.","DOI":"10.1016\/j.mayocp.2013.01.019"},{"key":"e_1_2_8_32_1","first-page":"3344","article-title":"Superior outcomes with bortezomib or thalidomide incorporated into autologous stem cell transplantation (ASCT) versus novel agent\u2010based treatments for Elderly patients with newly diagnosed multiple myeloma (MM): a case\u2010match comparison","volume":"122","author":"Zamagni E.","year":"2013","journal-title":"Blood"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2011.000312"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-011-0180-z"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2859"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-122"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccr3.76","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccr3.76","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.76","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.76","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.76","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T21:16:19Z","timestamp":1694726179000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.76"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,28]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1002\/ccr3.76"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.76","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,28]]}}}