{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:10:17Z","timestamp":1791645017222,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Key Clinical Message<\/jats:title><jats:p>Lethal multiple pterygium syndrome is a very rare genetic disorder. The manifestations of this condition include growth deficiency of the fetus, craniofacial anomalies, joint contracture, and skin webbing (pterygia). This disorder is fatal before birth or shortly after birth. We reported a case of lethal multiple pterygium syndrome with multiple anomalies including pterygia involving the axilla, bilateral antecubital fossa, and groin. Arthrogryposis involving multiple lower and upper extremities joints. Cleft palate, microstomia and limitation of mouth opening, webbed neck, asymmetric small and narrow chest, ambiguous genitalia, depressed and wide nasal bridge, antemongoloid slant, low\u2010set, malformed, and posteriorly rotated ears, pterygia, syndactyly and camptodactyly of hands and rocket bottom feet. LMPS is a congenital genetic disease with multiple anomalies that is fatal in the second and third trimesters of pregnancy or shortly after birth. With genetic testing and counseling, it can be prevented from recurring in subsequent pregnancies.<\/jats:p>","DOI":"10.1002\/ccr3.7678","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T13:13:38Z","timestamp":1689167618000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lethal multiple pterygium syndrome in a newborn, a case report"],"prefix":"10.1002","volume":"11","author":[{"given":"Parvaneh","family":"Sadeghimoghadam","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Vali\u2010E\u2010Asr Hospital, Imam Complex Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeedeh","family":"Shirdel","sequence":"additional","affiliation":[{"name":"Vali\u2010E\u2010Asr Reproductive Health Research Center Family Health Research Institute, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sedigheh","family":"Hantoushzadeh","sequence":"additional","affiliation":[{"name":"Vali\u2010E\u2010Asr Reproductive Health Research Center Family Health Research Institute, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Hashemi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Vali\u2010E\u2010Asr Hospital, Imam Complex Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2306-7112","authenticated-orcid":false,"given":"Marjan","family":"Ghaemi","sequence":"additional","affiliation":[{"name":"Vali\u2010E\u2010Asr Reproductive Health Research Center Family Health Research Institute, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,12]]},"reference":[{"issue":"6","key":"e_1_2_11_2_1","first-page":"609","article-title":"Multiple pterygium syndrome","volume":"132","author":"Escobar V","year":"1978","journal-title":"Am J Dis Child"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.27.12.791"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320120404"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320170410"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-016-0947-5"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320270418"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990101)82:1<97::AID-AJMG22>3.0.CO;2-G"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.04.004"},{"issue":"3","key":"e_1_2_11_10_1","first-page":"317","article-title":"Scoliosis in Escobar syndrome (multiple pterygium syndrome). 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