{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:08:40Z","timestamp":1753862920778,"version":"3.41.2"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>Toxoplasmosis\u2010related huge brain lesions may require decompressive craniectomy and lesion excision to avoid brain damage. In this situation, injectable cotrimoxazole is a better choice for treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Toxoplasma gondii is a worldly distributed obligate intracellular protozoa. Toxoplasmosis is a prevalent opportunistic infection in HIV\u2010infected people, but it was rarely recorded prior to the identification of HIV infection. Here, we report a toxoplasmosis brain lesion in an Iranian HIV\u2010positive patient. A 45\u2010year\u2010old woman with a complaint of malaise was referred to the Valiasr Hospital in Arak city. In her past clinical history, the patient had a history of anemia, deep vein thrombosis (DVT), and positive HIV. The patient was informed of the diagnosis of massive brain toxoplasmosis as a definite diagnosis. The patient was then taken to the operating room for a left decompressive craniectomy, during which the ensuing brain lesion was excised. After a few days, she was discharged from the hospital in good condition and without any complications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.7688","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T14:05:21Z","timestamp":1689257121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An <scp>HIV<\/scp>\u2010positive woman with massive brain lesion due to toxoplasmosis: A case report"],"prefix":"10.1002","volume":"11","author":[{"given":"Reza","family":"Ghasemikhah","sequence":"first","affiliation":[{"name":"Department of Parasitology &amp; Mycology Arak University of Medical Sciences  Arak Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Hakimzadeh","sequence":"additional","affiliation":[{"name":"Neurosciences Research Center (NSRC) Tabriz University of Medical Sciences  East Azerbaijan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0762-4815","authenticated-orcid":false,"given":"Abolfazl","family":"Gilani","sequence":"additional","affiliation":[{"name":"Sina Trauma &amp; Surgery Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Sarmadian","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Arak University of Medical Sciences  Arak Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0264-8903","authenticated-orcid":false,"given":"Roham","family":"Sarmadian","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Center Arak University of Medical Sciences  Arak Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Negin","family":"Yousefbeigi","sequence":"additional","affiliation":[{"name":"Department of Radiology Arak University of Medical Sciences  Arak Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,13]]},"reference":[{"issue":"1","key":"e_1_2_12_2_1","first-page":"32","article-title":"A case report of cerebral toxoplasmosis in an HIV\u2010positive patient: risk of possible transmission through contaminated water\/food","volume":"4","author":"Boughattas S","year":"2017","journal-title":"J Food Qual Hazards Control"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2009.02.004"},{"issue":"2","key":"e_1_2_12_4_1","first-page":"187","article-title":"Serological evaluation of anti\u2010toxoplasma gondii antibodies in patients with acute leukemia and lymphoma through chemotherapy","volume":"15","author":"Tabatabaie F","year":"2020","journal-title":"Iran J Parasitol"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofy259"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1556\/1886.2016.00030"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12163"},{"issue":"2","key":"e_1_2_12_8_1","first-page":"59","article-title":"Toxoplasmosis in immunocompromised patients","volume":"64","author":"Machala L","year":"2015","journal-title":"Epidemiol Mikrobiol Imunol"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.5847\/wjem.j.1920-8642.2017.01.012"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000000397"},{"key":"e_1_2_12_11_1","first-page":"1","article-title":"Approach to an intracranial mass in patients with HIV","volume":"20","author":"Isabel E","year":"2020","journal-title":"Curr Neurol Neurosci Rep"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.09.89"},{"issue":"4","key":"e_1_2_12_13_1","first-page":"316","article-title":"Cerebral toxoplasmosis in a patient with acquired immunodeficiency syndrome","volume":"60","author":"Naqi R","year":"2010","journal-title":"J Pak Med Assoc"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.5414\/NP300655"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.30.11.3000-3002.1992"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.287085135"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5070.190817"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268820000928"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/20477724.2022.2083977"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12402"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000000313"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.7688","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T08:40:57Z","timestamp":1692261657000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.7688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1002\/ccr3.7688"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.7688","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"2023-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e7688"}}