{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T10:47:42Z","timestamp":1792320462397,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T00:00:00Z","timestamp":1690675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>Linezolid (LZD) is an efficient addition antibiotic against multidrug\u2010resistant strains. However, clinicians should pay attention to the adverse reactions such as hypoglycemia and anemia in using LZD, especially in elderly patients and patients with abnormal liver and kidney function who need to use LZD for a long time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Severe hypoglycemia and anemia caused by linezolid (LZD) are rare, with potentially serious adverse effects. The report of LZD\u2010induced hypoglycemia and anemia is extremely rare. Thus far, this is the first report. We presented LZD\u2010induced recurrent hypoglycemia and anemia in a 93\u2010year\u2010old patient who has been prescribed LZD 600\u2009mg once daily for 42\u2009days for treatment of tuberculosis (TB) pleurisy and pneumonia. The patient began to experience recurrent hypoglycemic episodes and anemia 5\u2009days and 2\u2009weeks after LZD medication, respectively. Using Naranjo's Adverse Drug Reaction Assessment Scale, the patient scored 8 points with the category of \u201cprobable\u201d. His hypoglycemia and anemia gradually improved 1\u2009month after LZD withdrawal. Clinicians should pay attention to the adverse reactions such as hypoglycemia and anemia in using LZD, especially in elderly patients and patients with abnormal liver and kidney function who need to use LZD for a long time. Patients should regularly monitor blood routine, blood glucose, and liver and kidney functions during LZD exposure, which may avoid adverse reactions and improve their prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.7713","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T04:10:05Z","timestamp":1690776605000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Linezolid induced hypoglycemia and anemia: A case report"],"prefix":"10.1002","volume":"11","author":[{"given":"Xiao\u2010hua","family":"Lan","sequence":"first","affiliation":[{"name":"Air Force Medical Center, PLA  Beijing China"},{"name":"Graduate School of Hebei North University  Zhangjiakou Hebei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Hu","sequence":"additional","affiliation":[{"name":"Air Force Medical Center, PLA  Beijing China"},{"name":"Graduate School of China Medical University  Shenyang Liaoning Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5756-1330","authenticated-orcid":false,"given":"Yan\u2010jie","family":"Cao","sequence":"additional","affiliation":[{"name":"Air Force Medical Center, PLA  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"Air Force Medical Center, PLA  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi\u2010tao","family":"Ren","sequence":"additional","affiliation":[{"name":"Graduate School of China Medical University  Shenyang Liaoning Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010wei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Air Force Medical Center, PLA  Beijing China"},{"name":"Graduate School of Hebei North University  Zhangjiakou Hebei Province 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