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Phe406Leu). His symptoms were nonspecific. Chest computed tomography (CCT) showed bronchiectasis, a mosaic feature, and extensive calcifications in both lungs. In addition, bronchoscopy showed bronchitis obliterans which has rarely been reported as a complication in the literature. This case aimed to explore the mechanism of PAM and emphasize the role of gene analysis in diagnosing rare pediatric diseases. Finally, we undertook a review of the current literature containing SLC34A2 gene mutations to update the gene mutation spectrum of PAM.<\/jats:p>","DOI":"10.1002\/ccr3.7726","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T23:44:25Z","timestamp":1691711065000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Two novel gene mutations identified in a child with pulmonary alveolar microlithiasis complicated with bronchitis obliterans: A case report and literature review"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2761-9005","authenticated-orcid":false,"given":"Meiyu","family":"Zhang","sequence":"first","affiliation":[{"name":"Pediatric Department of Respiration The First Hospital of Jilin University  Changchun City 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